| Weight | 446.91 g/mol |
|---|---|
| Formula | C22H24ClFN4O3 |
| Hydrogen Acceptors | 7 |
| Hydrogen Donors | 1 |
| Aromatic Rings | 3 |
| Rotatable Bonds | 8 |
Gefitinib (184475-35-2)
Score:
#22 in Molecular and cellular biology
,
#749 in Biochemistry
,
#2539 in Chemistry
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- Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. (The New England Journal of Medicine, 2004)
- EGFR Mutations in Lung Cancer: Correlation with Clinical Response to Gefitinib Therapy (Science, 2004)
- Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma. (The New England Journal of Medicine, 2009)
- EGF receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumors to gefitinib and erlotinib. (Proceedings of the National Academy of Sciences of the United States of America, 2004)
- MET Amplification Leads to Gefitinib Resistance in Lung Cancer by Activating ERBB3 Signaling (Science, 2007)
- Gefitinib or Chemotherapy for Non-Small- Cell Lung Cancer with Mutated EGFR (The New England Journal of Medicine, 2010)
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Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. -
SMILESCOC1=C(C=C2C(=C1)N=CN=C2NC3=CC(=C(C=C3)F)Cl)OCCCN4CCOCC4
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InChIKeyXGALLCVXEZPNRQ-UHFFFAOYSA-N
- Pubchem - Gefitinib
- Wikipedia - gefitinib
Gefitinib (ZD1839) (INN, , trade name Iressa) is a drug used for certain breast, lung and other cancers. Gefitinib is an EGFR inhibitor, like erlotinib, which interrupts signaling through the epidermal growth factor receptor (EGFR) in target cells. Therefore, it is only effective in cancers with mutated and overactive EGFR.
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