Weight | 449.533 g/mol |
---|---|
Formula | C20H27N5O5S |
Hydrogen Acceptors | 7 |
Hydrogen Donors | 3 |
Aromatic Rings | 2 |
Rotatable Bonds | 7 |
Glisoxepide (25046-79-1)
Pro-diaban · 4-(4-beta-(5-methylisoxazol-3-carboxamidoethyl)phenylsulfonyl)-1,1-hexamethylenesemicarbazide · RP-22410
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- Pharmacodynamic aspects of tolbutamide, glibenclamide, glibornuride and glisoxepide (Diabetologia, 1971)
- Pharmacodynamic aspects of tolbutamide, glibenclamide, glibornuride, and glisoxepide. II. Repeated administration in combination with glucose. (Diabetologia, 1971)
- Pharmacological comparison between tolbutamide and two second generation hypoglycemic sulfonylureas (Glibenclamide and glisoxepide) (Acta Diabetologica, 1973)
- Precursor specific inhibition of hepatic gluconeogenesis by glisoxepide, an inhibitor of the L-aspartate/ L-glutamate antiport system (FEBS Letters, 1975)
- [Comparison of glibenclamide, gliquidone, glisoxepide and placebo in maturity onset diabetics of differing degrees of severity (author's transl)]. (Wiener Klinische Wochenschrift, 1979)
- [The toxicology of glisoxepide, a new oral antidiabetic. Results of animal studies]. (Drug Research, 1974)
-
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. - Pro-diaban
- 4-(4-beta-(5-methylisoxazol-3-carboxamidoethyl)phenylsulfonyl)-1,1-hexamethylenesemicarbazide
- RP-22410
- RP 22410
- BS 4231
- glisoxepid
- BS-4231
-
SMILESCC1=CC(=NO1)C(=O)NCCC2=CC=C(C=C2)S(=O)(=O)NC(=O)NN3CCCCCC3
-
InChIKeyZKUDBRCEOBOWLF-UHFFFAOYSA-N
- Pubchem - Glisoxepide
- Wikipedia - glisoxepide
Glisoxepide (INN) is an orally available anti-diabetic drug from the group of sulfonylureas. It belongs to second-generation sulfonylureas.
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Synthesis
AC1L2515
+
Reactant
(Friedel-Crafts alkylation)
5-Methylisoxazole-3-carbonyl chloride
+
Reactant
(Schotten-Baumann amide from acid)
5-Methylisoxazole-3-carboxamide
+
Reactant
(Alkylation of primary amines)
Reactant
+
1-Aminohomopiperidine
(Thiourea)
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