| Weight | 293.326 g/mol |
|---|---|
| Formula | C17H15N3O2 |
| Hydrogen Acceptors | 5 |
| Hydrogen Donors | 1 |
| Aromatic Rings | 2 |
| Rotatable Bonds | 1 |
Gyki-52466 (102771-26-6)
GYKI 52466 · 1-(p-aminophenyl)-4-methyl-7,8-methylenedioxy-5H-2,3-benzodiazepine hydrochloride
Score:
#1170 in Neuroscience
,
#5052 in Biology
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- GYKI 52466, a 2,3-benzodiazepine, is a highly selective, noncompetitive antagonist of AMPA/kainate receptor responses (Neuron, 1993)
- The non-NMDA antagonists, NBQX and GYKI 52466, protect against cortical and striatal cell loss following transient global ischaemia in the rat (Brain Research, 1992)
- The anticonvulsant effect of the non-NMDA antagonists, NBQX and GYKI 52466, in mice (Epilepsy Research, 1991)
- The non-N-methyl-D-aspartate receptor antagonists, GYKI 52466 and NBQX are anticonvulsant in two animal models of reflex epilepsy (European Journal of Pharmacology, 1991)
- Interactions of MK-801 and GYKI 52466 with morphine and amphetamine in place preference conditioning and behavioural sensitization (Behavioural Brain Research, 1997)
- Cerebroprotective effect of a non-N-methyl-D-aspartate antagonist, GYKI 52466, after focal ischemia in the rat. (Stroke, 1992)
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Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. - GYKI 52466
- 1-(p-aminophenyl)-4-methyl-7,8-methylenedioxy-5H-2,3-benzodiazepine hydrochloride
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SMILESCC1=NN=C(C2=CC3=C(C=C2C1)OCO3)C4=CC=C(C=C4)N
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InChIKeyLFBZZHVSGAHQPP-UHFFFAOYSA-N
- Pubchem - Gyki-52466
- Wikipedia - gyki-2466
GYKI-52466 is a 2,3-benzodiazepine that acts as an ionotropic glutamate receptor antagonist, which is a non-competitive AMPA receptor antagonist (IC50 values are 10-20, ~ 450 and >> 50 M for AMPA- , kainate- and NMDA-induced responses respectively), orally-active anticonvulsant, and skeletal muscle relaxant. Unlike conventional 1,4-benzodiazepines, GYKI-52466 and related 2,3-benzodiazepines do not act on GABAA receptors. Like other AMPA receptor antagonists, GYKI-52466 has anticonvulsant and neuroprotective properties.
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