| Weight | 414.687 g/mol |
|---|---|
| Formula | C16H17BrClN3O3 |
| Hydrogen Acceptors | 6 |
| Hydrogen Donors | 2 |
| Aromatic Rings | 2 |
| Rotatable Bonds | 4 |
Halofuginone (55837-20-2)
Score:
#2092 in Biochemistry
,
#4338 in Biology
,
#5471 in Chemistry
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- Halofuginone Inhibits TH17 Cell Differentiation by Activating the Amino Acid Starvation Response (Science, 2009)
- Amelioration of Radiation-induced Fibrosis INHIBITION OF TRANSFORMING GROWTH FACTOR- SIGNALING BY HALOFUGINONE (Journal of Biological Chemistry, 2004)
- Halofuginone, an Inhibitor of Type-I Collagen Synthesis and Skin Sclerosis, Blocks Transforming-Growth-Factor--Mediated Smad3 Activation in Fibroblasts (Journal of Investigative Dermatology, 2002)
- Halofuginone to prevent and treat thioacetamide-induced liver fibrosis in rats (Hepatology, 2001)
- Halofuginone to Treat Fibrosis in Chronic Graft- versus-Host Disease and Scleroderma (Biology of Blood and Marrow Transplantation, 2003)
- Halofuginone: a novel antifibrotic therapy. (General Pharmacology-the Vascular System, 1998)
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Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. -
SMILESC1CC(C(NC1)CC(=O)CN2C=NC3=CC(=C(C=C3C2=O)Cl)Br)O
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InChIKeyLVASCWIMLIKXLA-UHFFFAOYSA-N
- Pubchem - Halofuginone
- Wikipedia - Halofuginone
Halofuginone is a coccidiostat used in veterinary medicine. It is a synthetic halogenated derivative of febrifugine, a natural quinazolinone alkaloid which can be found in the Chinese herb Dichroa febrifuga (Chang Shan). Collgard Biopharmaceuticals is developing halofuginone for the treatment of scleroderma and it has received orphan drug designation from the U.S.
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