Weight | 204.229 g/mol |
---|---|
Formula | C11H12N2O2 |
Hydrogen Acceptors | 4 |
Hydrogen Donors | 1 |
Aromatic Rings | 1 |
Rotatable Bonds | 1 |
IDAZOXAN (79944-58-4)
Score:
#1150 in Neuroscience
,
#4973 in Biology
,
#6384 in Chemistry
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- The antidepressants fluoxetine, idazoxan and phenelzine alter corticotropin-releasing hormone and tyrosine hydroxylase mRNA levels in rat brain: therapeutic implications (Brain Research, 1992)
- Presynaptic alpha-2 adrenoceptors play a major role in the effects of idazoxan on cortical noradrenaline release (as measured by in vivo dialysis) in the rat (Journal of Pharmacology and Experimental Therapeutics, 1987)
- Anatomical evidence for alpha-2 adrenoceptor heterogeneity: differential autoradiographic distributions of [3H]rauwolscine and [3H]idazoxan in rat brain. (Journal of Pharmacology and Experimental Therapeutics, 1987)
- An imidazoline-specific mechanism for the hypotensive effect of clonidine: a study with yohimbine and idazoxan. (Journal of Pharmacology and Experimental Therapeutics, 1991)
- [3H]idazoxan and some other alpha 2-adrenergic drugs also bind with high affinity to a nonadrenergic site. (Molecular Pharmacology, 1989)
- Comparison of the -adrenoceptor antagonist profiles of idazoxan (RX 781094), yohimbine, rauwolscine and corynanthine (Naunyn-schmiedebergs Archives of Pharmacology, 1984)
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Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. -
SMILESC1CN=C(N1)C2COC3=CC=CC=C3O2
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InChIKeyHPMRFMKYPGXPEP-UHFFFAOYSA-N
- Pubchem - IDAZOXAN
- Wikipedia - idazoxan
Idazoxan (INN) is a drug which is used in scientific research. It acts as both a selective 2 adrenergic receptor antagonist, and an antagonist for the imidazoline receptor. Idazoxan has been under investigation as an antidepressant, but it did not reach the market as such.
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