| Weight | 213.214 g/mol |
|---|---|
| Formula | C8H7NO4S |
| Hydrogen Acceptors | 3 |
| Hydrogen Donors | 2 |
| Aromatic Rings | 2 |
| Rotatable Bonds | 2 |
Indoxyl sulfate (487-94-5, 1336-79-4)
Score:
#1567 in Biochemistry
,
#3603 in Biology
,
#4521 in Chemistry
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- Serum Indoxyl Sulfate Is Associated with Vascular Disease and Mortality in Chronic Kidney Disease Patients (Clinical Journal of The American Society of Nephrology, 2009)
- Indoxyl sulfate, a circulating uremic toxin, stimulates the progression of glomerular sclerosis. (Journal of Laboratory and Clinical Medicine, 1994)
- The uremic solutes p-cresol and indoxyl sulfate inhibit endothelial proliferation and wound repair (Kidney International, 2004)
- Role of Organic Anion Transporters in the Tubular Transport of Indoxyl Sulfate and the Induction of its Nephrotoxicity (Journal of The American Society of Nephrology, 2002)
- The uremic solute indoxyl sulfate induces oxidative stress in endothelial cells (Journal of Thrombosis and Haemostasis, 2007)
- The protein metabolite hypothesis, a model for the progression of renal failure: An oral adsorbent lowers indoxyl sulfate levels in undialyzed uremic patients (Kidney International, 1997)
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Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. -
SMILESC1=CC=C2C(=C1)C(=CN2)OS(=O)(=O)O
-
InChIKeyBXFFHSIDQOFMLE-UHFFFAOYSA-N
- Pubchem - Indoxyl sulfate
- Wikipedia - indoxyl sulfate
Indoxyl sulfate, also known as 3-indoxylsulfate and 3-indoxylsulfuric acid, is a metabolite of dietary L-tryptophan that acts as a cardiotoxin and uremic toxin. High concentrations of indoxyl sulfate in blood plasma are known to be associated with the development and progression of chronic kidney disease and vascular disease in humans. As a uremic toxin, it stimulates glomerular sclerosis and renal interstitial fibrosis.
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