| Weight | 246.306 g/mol |
|---|---|
| Formula | C15H18O3 |
| Hydrogen Acceptors | 3 |
| Hydrogen Donors | 2 |
| Aromatic Rings | 0 |
| Rotatable Bonds | 1 |
Irofulven (158440-71-2)
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- Anti-tumour compounds illudin S and Irofulven induce DNA lesions ignored by global repair and exclusively processed by transcription- and replication-coupled repair pathways (DNA Repair, 2002)
- Irofulven cytotoxicity depends on transcription-coupled nucleotide excision repair and is correlated with XPG expression in solid tumor cells. (Clinical Cancer Research, 2004)
- Phase I and Pharmacokinetic Study of Irofulven, a Novel Mushroom-Derived Cytotoxin, Administered for Five Consecutive Days Every Four Weeks in Patients With Advanced Solid Malignancies (Journal of Clinical Oncology, 2000)
- Enantioselective Total Synthesis of ()Acylfulvene and ()Irofulven (Angewandte Chemie, 2006)
- Synthesis and biological activity of enantiomers of antitumor irofulven. (Journal of Organic Chemistry, 2004)
- Marked Activity of Irofulven toward Human Carcinoma Cells Comparison with Cisplatin and Ecteinascidin (Clinical Cancer Research, 2003)
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Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. -
SMILESCC1=C(C2=C(C3(CC3)C(C(=O)C2=C1)(C)O)C)CO
-
InChIKeyNICJCIQSJJKZAH-UHFFFAOYSA-N
- Pubchem - Irofulven
- Wikipedia - irofulven
Irofulven or 6-hydroxymethylacylfulvene (also known as HMAF of MGI-114) is an experimental antitumor agent. It belongs to the family of drugs called alkylating agents. It inhibits the replication of DNA in cell culture.
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