| Weight | 468.594 g/mol |
|---|---|
| Formula | C27H36N2O5 |
| Hydrogen Acceptors | 6 |
| Hydrogen Donors | 0 |
| Aromatic Rings | 2 |
| Rotatable Bonds | 10 |
Ivabradine (155974-00-8)
Score:
#13 in Physiology
,
#1049 in Biochemistry
,
#2717 in Biology
,
#3403 in Chemistry
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- Ivabradine and outcomes in chronic heart failure (SHIFT): a randomised placebo-controlled study (The Lancet, 2010)
- Ivabradine for patients with stable coronary artery disease and left-ventricular systolic dysfunction (BEAUTIFUL): a randomised, double-blind, placebo-controlled trial. (The Lancet, 2008)
- Efficacy of ivabradine, a new selective If inhibitor, compared with atenolol in patients with chronic stable angina (European Heart Journal, 2005)
- Antianginal and Antiischemic Effects of Ivabradine, an If Inhibitor, in Stable Angina A Randomized, Double-Blind, Multicentered, Placebo-Controlled Trial (Circulation, 2003)
- Heart rate lowering by specific and selective If current inhibition with ivabradine: A new therapeutic perspective in cardiovascular disease (Drugs, 2004)
- Long-Term Heart Rate Reduction Induced by the Selective If Current Inhibitor Ivabradine Improves Left Ventricular Function and Intrinsic Myocardial Structure in Congestive Heart Failure (Circulation, 2004)
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Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. -
SMILESCN(CCCN1CCC2=CC(=C(C=C2CC1=O)OC)OC)CC3CC4=CC(=C(C=C34)OC)OC
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InChIKeyACRHBAYQBXXRTO-UHFFFAOYSA-N
- Pubchem - Ivabradine
- Wikipedia - ivabradine
Ivabradine, marketed under the trade name Corlanor among others, is a medication used for the symptomatic management of stable heart-related chest pain and heart failure not fully managed by beta blockers. Ivabradine acts by reducing the heart rate via specific inhibition of the funny channel, a mechanism different from that of beta blockers and calcium channel blockers, two commonly prescribed antianginal drugs. Ivabradine is a cardiotonic agent.
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