| Weight | 250.298 g/mol |
|---|---|
| Formula | C13H18N2O3 |
| Hydrogen Acceptors | 3 |
| Hydrogen Donors | 2 |
| Aromatic Rings | 1 |
| Rotatable Bonds | 6 |
Lacosamide (175481-36-4, 175481-26-2)
Score:
#111 in Neurology
,
#527 in Neuroscience
,
#2427 in Biology
,
#3019 in Chemistry
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- Efficacy and Safety of Oral Lacosamide as Adjunctive Therapy in Adults with PartialOnset Seizures (Epilepsia, 2007)
- The investigational anticonvulsant lacosamide selectively enhances slow inactivation of voltage-gated sodium channels (Molecular Pharmacology, 2007)
- Adjunctive lacosamide for partial-onset seizures : Efficacy and safety results from a randomized controlled trial (Epilepsia, 2009)
- Lacosamide: A Review of Preclinical Properties (Cns Drug Reviews, 2007)
- Lacosamide as adjunctive therapy for partialonset seizures: A randomized controlled trial (Epilepsia, 2010)
- Differential Block of Sensory Neuronal Voltage-Gated Sodium Channels by Lacosamide [(2R)-2-(Acetylamino)-N-benzyl-3-methoxypropanamide], Lidocaine, and Carbamazepine (Journal of Pharmacology and Experimental Therapeutics, 2008)
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SMILESCC(=O)NC(COC)C(=O)NCC1=CC=CC=C1
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- Pubchem - Lacosamide
- Wikipedia - lacosamide
Lacosamide (INN, formerly known as erlosamide, harkeroside, SPM 927, or ADD 234037), is a medication for the adjunctive treatment of partial-onset seizures and diabetic neuropathic pain. It is marketed under the trade name Vimpat.
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Alternate Names
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Synthesis
ACETYL CHLORIDE
+
Reactant
(Schotten-Baumann amide from acid)
benzaldehyde
+
Reactant
(Reductive amination)
acetamide
+
Reactant
(Alkylation of primary amines)
Reactant
+
dimethyl sulfide
(Corey-Kim oxidation of secondary alcohols)
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1 alternate name
3 suppliers
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triallate
(2303-17-5)
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(26087-47-8)
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Lacosamide
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