| Weight | 391.474 g/mol |
|---|---|
| Formula | C26H21N3O |
| Hydrogen Acceptors | 3 |
| Hydrogen Donors | 0 |
| Aromatic Rings | 4 |
| Rotatable Bonds | 5 |
Linopirdine (105431-72-9)
3,3-bis(4-pyridylmethyl)-1-phenylindolin-2-one · 3,3-dipyridylmethyl-1-phenyl-2-indolinone · DuP 996
Score:
#1202 in Neuroscience
,
#5168 in Biology
,
#6751 in Chemistry
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- Reduction of spike frequency adaptation and blockade of M-current in rat CA1 pyramidal neurones by linopirdine (DuP 996), a neurotransmitter release enhancer (British Journal of Pharmacology, 1995)
- Effects of a Cognitionenhancer, Linopirdine (DuP 996), on Mtype Potassium Currents (IK(M)) Some Other Voltage and Ligandgated Membrane Currents in Rat Sympathetic Neurons (European Journal of Neuroscience, 1997)
- Selectivity of Linopirdine (DuP 996), a Neurotransmitter Release Enhancer, in Blocking Voltage-Dependent and Calcium-Activated Potassium Currents in Hippocampal Neurons (Journal of Pharmacology and Experimental Therapeutics, 1998)
- Two new potent neurotransmitter release enhancers, 10,10-bis(4-pyridinylmethyl)-9(10H)-anthracenone and 10,10-bis(2-fluoro-4-pyridinylmethyl)-9(10H)-anthracenone: comparison to linopirdine. (Journal of Pharmacology and Experimental Therapeutics, 1998)
- Linopirdine (DuP 996) improves performance in several tests of learning and memory by modulation of cholinergic neurotransmission (Pharmacology, Biochemistry and Behavior, 1994)
- Pharmacology of the Neurotransmitter Release Enhancer Linopirdine (DuP 996), and Insights into Its Mechanism of Action (Advances in pharmacology, 1996)
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Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. - 3,3-bis(4-pyridylmethyl)-1-phenylindolin-2-one
- 3,3-dipyridylmethyl-1-phenyl-2-indolinone
- DuP 996
- DuP-996
-
SMILESC1=CC=C(C=C1)N2C3=CC=CC=C3C(C2=O)(CC4=CC=NC=C4)CC5=CC=NC=C5
-
InChIKeyYEJCDKJIEMIWRQ-UHFFFAOYSA-N
- Pubchem - Linopirdine
- Wikipedia - linopirdine
Linopirdine is a putative cognition-enhancing drug with a novel mechanism of action. Linopirdine blocks the KCNQ2\3 heteromer M current with an IC50 of 2.4nM disinhibiting acetylcholine release, and increasing hippocampal CA3-schaffer collateral mediated glutamate release onto CA1 pyramidal neurons. In a murine model linopirdine is able to nearly completely reverse the senescence-related decline in cortical c-FOS, an effect which is blocked by atropine and MK-801, suggesting Linopirdine can compensate for the age related decline in acetylcholine release.
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