Weight | 233.699 g/mol |
---|---|
Formula | C9H16ClN3O2 |
Hydrogen Acceptors | 3 |
Hydrogen Donors | 1 |
Aromatic Rings | 0 |
Rotatable Bonds | 4 |
lomustine (13010-47-4)
CCNU · CeeNU · NSC-79037
Score:
#147 in Neuroscience
,
#171 in Biochemistry
,
#722 in Biology
,
#781 in Chemistry
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- Sigma-Aldrich - lomustine112.00 - 338.10 USD
- Fisher Scientific - Search for lomustine
- TCI - lomustine43.00 - 208.00 USD
- Adjuvant procarbazine, lomustine, and vincristine improves progression-free survival but not overall survival in newly diagnosed anaplastic oligodendrogliomas and oligoastrocytomas: a randomized European Organisation for Research and Treatment of Cancer phase III trial. (Journal of Clinical Oncology, 2006)
- NOA-04 Randomized Phase III Trial of Sequential Radiochemotherapy of Anaplastic Glioma With Procarbazine, Lomustine, and Vincristine or Temozolomide (Journal of Clinical Oncology, 2009)
- The treatment of medulloblastoma Results of a prospective randomized trial of radiation therapy with and without CCNU, vincristine, and prednisone (Journal of Neurosurgery, 1990)
- Adjuvant Procarbazine, Lomustine, and Vincristine Chemotherapy in Newly Diagnosed Anaplastic Oligodendroglioma: Long-Term Follow-Up of EORTC Brain Tumor Group Study 26951 (Journal of Clinical Oncology, 2013)
- Outcome for children with medulloblastoma treated with radiation and cisplatin, CCNU, and vincristine chemotherapy (Journal of Neurosurgery, 1994)
- Superiority of post-radiotherapy adjuvant chemotherapy with CCNU, procarrazine, and vincristine (PCV) over BCNU for anaplastic gliomas: NCOG 6G61 final report (International Journal of Radiation Oncology Biology Physics, 1990)
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Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. - H301: Toxic if swallowed
Danger Acute toxicity, oral - Category 3 - H350: May cause cancer
Danger Carcinogenicity - Category 1A, 1B - H370: Causes damage to organs
Danger Specific target organ toxicity, single exposure - Category 1 - CCNU
- CeeNU
- NSC-79037
- Belustine
- Cecenu
- NSC 79037
- NSC79037
-
SMILESC1CCC(CC1)NC(=O)N(CCCl)N=O
-
InChIKeyGQYIWUVLTXOXAJ-UHFFFAOYSA-N
- Pubchem - lomustine
- Wikipedia - lomustine
Lomustine (INN), abbreviated CCNU (original brand name (formerly available) is CeeNU, now marketed as Gleostine), is an alkylating nitrosourea compound used in chemotherapy. It is closely related to semustine and is in the same family as streptozotocin. It is a highly lipid-soluble drug, thus it crosses the blood-brain barrier.
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