| Weight | 433.524 g/mol |
|---|---|
| Formula | C22H25F2N3O2S |
| Hydrogen Acceptors | 6 |
| Hydrogen Donors | 1 |
| Aromatic Rings | 3 |
| Rotatable Bonds | 7 |
Lubeluzole (144665-07-6)
Score:
#1078 in Neuroscience
,
#4671 in Biology
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- Lubeluzole Treatment of Acute Ischemic Stroke (Stroke, 1997)
- Lubeluzole in Acute Ischemic Stroke A Double-blind, Placebo-Controlled Phase II Trial (Stroke, 1996)
- Lubeluzole in acute ischemic stroke treatment: A double-blind study with an 8-hour inclusion window comparing a 10-mg daily dose of lubeluzole with placebo (Stroke, 2000)
- Multinational Randomised Controlled Trial of Lubeluzole in Acute Ischaemic Stroke (Cerebrovascular Diseases, 1998)
- Lubeluzole protects sensorimotor function and reduces infarct size in a photochemical stroke model in rats. (Journal of Pharmacology and Experimental Therapeutics, 1996)
- Neuroprotection of lubeluzole is mediated through the signal transduction pathways of nitric oxide (Journal of Neurochemistry, 2002)
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Predict GHS Hazards for Any Chemical in silico.
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SMILESCN(C1CCN(CC1)CC(COC2=CC(=C(C=C2)F)F)O)C3=NC4=CC=CC=C4S3
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- Pubchem - Lubeluzole
- Wikipedia - lubeluzole
Lubeluzole (Prosynap) is a drug which acts as an indirect NMDA antagonist. It inhibits the release of glutamate, inhibits nitric oxide synthesis, and blocks calcium and sodium gated ion channels. It has neuroprotective effects particularly in hypoxic conditions, and was developed for the treatment of stroke.
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