Weight | 401.274 g/mol |
---|---|
Formula | C9H19Cl2N2O5PS2 |
Hydrogen Acceptors | 5 |
Hydrogen Donors | 2 |
Aromatic Rings | 0 |
Rotatable Bonds | 9 |
Mafosfamide (88859-04-5)
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SMILESC1COP(=O)(NC1SCCS(=O)(=O)O)N(CCCl)CCCl
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- Pubchem - Mafosfamide
- Wikipedia - mafosfamide
Mafosfamide (INN) is an oxazaphosphorine (cyclophosphamide-like) alkylating agent under investigation as a chemotherapeutic. It is metabolized by cytochrome P450 into 4-hydroxycyclophosphamide, which is then converted into aldophosphamide, which, in turn yields the cytotoxic metabolites phosphoramide mustard and acrolein. Several Phase I trials have been completed.
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