| Weight | 284.36 g/mol |
|---|---|
| Formula | C13H24N4O3 |
| Hydrogen Acceptors | 4 |
| Hydrogen Donors | 4 |
| Aromatic Rings | 0 |
| Rotatable Bonds | 7 |
MELANOSTATIN (9083-38-9, 2002-44-0)
Pro-Leu-Glyamide · Prolyl Leucyl Glycinamide · Melanocyte-Stimulating Hormone Release-Inhibiting Factor
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- Prolyl-leucyl-glycinamide (PLG) facilitates morphine dependence. (Life Sciences, 1976)
- Prolyl-leucyl-glycinamide, cyclo(leucylglycine), and derivatives block development of physical dependence on morphine in mice. (Proceedings of the National Academy of Sciences of the United States of America, 1979)
- Characterization of melanotropin-release-inhibiting factor (melanostatin) from frog brain: homology with human neuropeptide Y (Proceedings of the National Academy of Sciences of the United States of America, 1991)
- Dose-related biphasic effect of prolyl-leucyl-glycinamide (MIF-I) in depression. (American Journal of Psychiatry, 1978)
- Effect of L-prolyl-L-leucyl-glycinamide (PLG) on neuroleptic-induced catalepsy and dopamine/neuroleptic receptor bindings (Peptides, 1981)
- Neuroleptic drug-induced dopamine receptor supersensitivity: antagonism by L-prolyl-L-leucyl-glycinamide (Science, 1981)
-
Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. - Pro-Leu-Glyamide
- Prolyl Leucyl Glycinamide
- Melanocyte-Stimulating Hormone Release-Inhibiting Factor
- MIF-I
- Prol-Leu-Gly-NH2
- MSH Release-Inhibiting Factor
- Prolyl-Leucyl-Glycinamide
- Prolylleucylglycinamide
- Pro-Leu-Gly-NH2
- Melanocyte-Stimulating Hormone Release-Inhibiting Hormone
- Oxytocin (7-9)
- H-Pro-Leu-Gly-NH2
- MIF-1
- MSH Release-Inhibiting Hormone
- Prol Leu Gly NH2
-
SMILESCC(C)CC(C(=O)NCC(=O)N)NC(=O)C1CCCN1
-
InChIKeyNOOJLZTTWSNHOX-UHFFFAOYSA-N
- Pubchem - MELANOSTATIN
- Wikipedia - Melanocyte-inhibiting factor
Melanocyte-inhibiting factor (also known as Pro-Leu-Gly-NH2, Melanostatin, MSH releaseinhibiting hormone or MIF-1) is an endogenous peptide fragment derived from cleavage of the hormone oxytocin, but having generally different actions in the body. MIF-1 produces multiple effects, both blocking the effects of opioid receptor activation, while at the same time acting as a positive allosteric modulator of the D2 and D4 dopamine receptor subtypes, as well as inhibiting release of other neuropeptides such as alpha-MSH, and potentiating melatonin activity. This complex mix of actions produces a profile of antidepressant, nootropic, and anti-Parkinsonian effects when MIF-1 is administered, and it has been investigated for various medical uses.
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Synthesis
L-prolinamide
+
Reactant
(Alkylation of primary amines)
Reactant
+
dimethyl sulfide
(Corey-Kim oxidation of secondary alcohols)
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