| Weight | 516.55 g/mol |
|---|---|
| Formula | C29H28N2O7 |
| Hydrogen Acceptors | 7 |
| Hydrogen Donors | 1 |
| Aromatic Rings | 4 |
| Rotatable Bonds | 11 |
Muraglitazar (331741-94-7)
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- Effect of Muraglitazar on Death and Major Adverse Cardiovascular Events in Patients With Type 2 Diabetes Mellitus (JAMA, 2005)
- Improvement of Glycemic Control, Triglycerides, and HDL Cholesterol Levels With Muraglitazar, a Dual (/) Peroxisome ProliferatorActivated Receptor Activator, in Patients With Type 2 Diabetes Inadequately Controlled With Metformin Monotherapy: A double-blind, randomized, pioglitazone-comparative study (Diabetes Care, 2006)
- Muraglitazar, a dual (/) PPAR activator: A randomized, double-blind, placebo-controlled, 24-week monotherapy trial in adult patients with type 2 diabetes (Clinical Therapeutics, 2005)
- Design and synthesis of N-[(4-methoxyphenoxy)carbonyl]-N-[[4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]phenyl]methyl]glycine [muraglitazar/BMS-298585], a novel peroxisome proliferator-activated receptor / dual agonist with efficacious glucose and lipid-lowering activities (Journal of Medicinal Chemistry, 2005)
- Improvement of Glycemic Control, Triglycerides, and HDL Cholesterol Levels With Muraglitazar, a Dual (/) Peroxisome ProliferatorActivated Receptor Activator, in Patients With Type 2 Diabetes Inadequately Controlled With Metformin Monotherapy (Diabetes Care, 2006)
- Urothelial Carcinogenesis in the Urinary Bladder of Male Rats Treated with Muraglitazar, a PPAR/ Agonist: Evidence for Urolithiasis as the Inciting Event in the Mode of Action (Toxicologic Pathology, 2006)
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Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. -
SMILESCC1=C(N=C(O1)C2=CC=CC=C2)CCOC3=CC=C(C=C3)CN(CC(=O)O)C(=O)OC4=CC=C(C=C4)OC
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- Pubchem - Muraglitazar
- Wikipedia - muraglitazar
Muraglitazar (proposed tradename Pargluva) is a dual peroxisome proliferator-activated receptor agonist with affinity to PPAR and PPAR. The drug had completed phase III clinical trials, however in May, 2006 Bristol-Myers Squibb announced that it had discontinued further development. Data on muraglitazar is relatively sparse due to the recent introduction of this agent.
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Synthesis
5-Methyl-2-phenyloxazole
+
Reactant
(Friedel-Crafts alkylation)
Reactant
+
CHLOROBENZENE
(Decarboxylative coupling)
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