| Weight | 312.804 g/mol |
|---|---|
| Formula | C17H17ClN4 |
| Hydrogen Acceptors | 4 |
| Hydrogen Donors | 2 |
| Aromatic Rings | 2 |
| Rotatable Bonds | 1 |
N-Desmethylclozapine (6104-71-8)
norclozapine · desmethylclozapine · 8-chloro-11-piperazin-1-yl-5H-dibenzo(B,E)(1,4)diazepine
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- Sigma-Aldrich - N-Desmethylclozapine116.00 - 173.00 USD
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- Clozapine and norclozapine plasma concentrations and clinical response of treatment-refractory schizophrenic patients. (American Journal of Psychiatry, 1991)
- N-desmethylclozapine, an allosteric agonist at muscarinic 1 receptor, potentiates N-methyl-d-aspartate receptor activity (Proceedings of the National Academy of Sciences of the United States of America, 2003)
- The role of M1 muscarinic receptor agonism of N-desmethylclozapine in the unique clinical effects of clozapine (Psychopharmacology, 2004)
- Intrinsic Efficacy of Antipsychotics at Human D2, D3, and D4 Dopamine Receptors: Identification of the Clozapine Metabolite N-Desmethylclozapine as a D2/D3 Partial Agonist (Journal of Pharmacology and Experimental Therapeutics, 2005)
- Serum levels of clozapine and norclozapine in patients treated with selective serotonin reuptake inhibitors (American Journal of Psychiatry, 1996)
- Relationship between plasma concentrations of clozapine and norclozapine and therapeutic response in patients with schizophrenia resistant to conventional neuroleptics (Psychopharmacology, 2000)
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Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. - norclozapine
- desmethylclozapine
- 8-chloro-11-piperazin-1-yl-5H-dibenzo(B,E)(1,4)diazepine
-
SMILESC1CN(CCN1)C2=C3C=CC=CC3=NC4=C(N2)C=C(C=C4)Cl
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InChIKeyHESZUPIXRNZIOI-UHFFFAOYSA-N
- Pubchem - N-Desmethylclozapine
- Wikipedia - norclozapine
N-Desmethylclozapine (NDMC), or norclozapine, is a major active metabolite of the atypical antipsychotic drug clozapine. Unlike clozapine, it possesses intrinsic activity at the D2/D3 receptors, and acts as a weak partial agonist at these sites similarly to aripiprazole and bifeprunox. Notably, NDMC has also been shown to act as a potent and efficacious agonist at the M1 and -opioid receptors, unlike clozapine as well.
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N-Desmethylclozapine
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