N-ethylmaleimide (128-53-0)

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  5 g
  $44.00

  25 g
  $131.00

Most-cited Publications

• Interaction of the N-EthylmaleimideSensitive Factor with AMPA Receptors (Neuron, 1998)
• N-ethylmaleimide-sensitive fusion protein: a trimeric ATPase whose hydrolysis of ATP is required for membrane fusion. (Journal of Cell Biology, 1994)
• Purification of an N-ethylmaleimide-sensitive protein catalyzing vesicular transport. (Proceedings of the National Academy of Sciences of the United States of America, 1988)
• Nitric Oxide Regulates Exocytosis by S-Nitrosylation of N-ethylmaleimide-Sensitive Factor (Cell, 2003)
• Crystal Structure of the Hexamerization Domain of N-ethylmaleimideSensitive Fusion Protein (Cell, 1998)
• Reactions of N-ethylmaleimide with peptides and amino acids (Biochemical Journal, 1964)

Areas of Application

Safety

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Trends

Alternate Names

• Ethylmaleimide
• N Ethylmaleimide
• SMILES
  CCN1C(=O)C=CC1=O
• InChIKey
  HDFGOPSGAURCEO-UHFFFAOYSA-N

External Links

• Pubchem - N-ethylmaleimide
• Wikipedia - N-ethylmaleimide
  N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.

Synthesis

Ethylboronic acid  +  MALEIMIDE (Chan-Lam coupling reaction)

Reactant  +  dimethyl sulfide (Corey-Kim oxidation of secondary alcohols)

Synthesis of N-ethylmaleimide ›

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