| Weight | 223.703 g/mol |
|---|---|
| Formula | C12H14ClNO |
| Hydrogen Acceptors | 2 |
| Hydrogen Donors | 1 |
| Aromatic Rings | 1 |
| Rotatable Bonds | 1 |
norketamine (35211-10-0)
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- Norketamine, the main metabolite of ketamine, is a non-competitive NMDA receptor antagonist in the rat cortex and spinal cord (European Journal of Pharmacology, 1997)
- Ketamine and norketamine plasma concentrations after i.v., nasal and rectal administration in children. (BJA: British Journal of Anaesthesia, 1996)
- Plasma concentration profiles of ketamine and norketamine after administration of various ketamine preparations to healthy Japanese volunteers. (Biopharmaceutics & Drug Disposition, 2003)
- Comparative pharmacology in the rat of ketamine and its two principal metabolites, norketamine and (Z)-6-hydroxynorketamine (Journal of Medicinal Chemistry, 1986)
- Oral ketamine is antinociceptive in the rat formalin test : role of the metabolite, norketamine (Pain, 1999)
- Urine Concentrations of Ketamine and Norketamine Following Illegal Consumption (Journal of Analytical Toxicology, 2001)
-
Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. -
SMILESC1CCC(C(=O)C1)(C2=CC=CC=C2Cl)N
-
InChIKeyBEQZHFIKTBVCAU-UHFFFAOYSA-N
- Pubchem - norketamine
- Wikipedia - norketamine
Norketamine, or N-desmethylketamine, is the major active metabolite of ketamine, which is formed mainly by CYP3A4. Similarly to ketamine, norketamine acts as a noncompetitive NMDA receptor antagonist (Ki = 1.7 M and 13 M for (S)-(+)-norketamine and (R)-()-norketamine, respectively), but is about 35 times less potent as an anesthetic in comparison. Also, similarly again to ketamine, norketamine binds to the - and -opioid receptors.
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