| Weight | 370.468 g/mol |
|---|---|
| Formula | C22H27FN2O2 |
| Hydrogen Acceptors | 3 |
| Hydrogen Donors | 0 |
| Aromatic Rings | 2 |
| Rotatable Bonds | 7 |
Ocfentanil (101343-69-5)
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SMILESCOCC(=O)N(C1CCN(CC1)CCC2=CC=CC=C2)C3=CC=CC=C3F
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- Pubchem - Ocfentanil
- Wikipedia - ocfentanil
Ocfentanil (INN) (also called A-3217) is a potent synthetic opioid structurally related to fentanyl that was developed in the early 1990s as one of a series of potent naloxone-reversible opioids in an attempt to obtain an opioid that had better therapeutic indices in terms of cardiovascular effects and respiratory depression as compared to fentanyl. Study of the analgesic activity of ocfentanil using the mouse hot plate test (55C) gave an ED50 of 0.007mg/kg compared to 0.018mg/kg for fentanyl; ocfentanil being approximately 2.5 times as potent as fentanyl in this test. In human volunteers ocfentanil induces effective analgesia at 1 g/kg, while in doses up to 3 g/kg, analgesia and respiratory depression occurred in a dose-dependent manner.
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