| Weight | 606.638 g/mol |
|---|---|
| Formula | C35H41Cl2N3O2 |
| Hydrogen Acceptors | 3 |
| Hydrogen Donors | 0 |
| Aromatic Rings | 3 |
| Rotatable Bonds | 8 |
Osanetant (160492-56-8)
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- A Tachykinin NK3Receptor Antagonist, SR 142801 (Osanetant), Prevents Substance P-induced Bronchial Hyperreactivity in Guinea-pigs (Pulmonary Pharmacology & Therapeutics, 1997)
- Randomized, double-blind study of SR142801 (Osanetant). A novel neurokinin-3 (NK3) receptor antagonist in panic disorder with pre- and posttreatment cholecystokinin tetrapeptide (CCK-4) challenges. (Pharmacopsychiatry, 2005)
- Me-Talnetant and Osanetant Interact within Overlapping but Not Identical Binding Pockets in the Human Tachykinin Neurokinin 3 Receptor Transmembrane Domains (Molecular Pharmacology, 2008)
- Osanetant Sanofi-Synthlabo. (Current opinion in investigational drugs, 2001)
- Identification of a critical residue in the transmembrane domain 2 of tachykinin neurokinin 3 receptor affecting the dissociation kinetics and antagonism mode of osanetant (SR 142801) and piperidine-based structures. (Journal of Medicinal Chemistry, 2009)
- Neurokinin-3 Receptor-Specific Antagonists Talnetant and Osanetant Show Distinct Mode of Action in Cellular Ca2+ Mobilization but Display Similar Binding Kinetics and Identical Mechanism of Binding in Ligand Cross-Competition (Molecular Pharmacology, 2006)
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Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. -
SMILESCC(=O)N(C)C1(CCN(CC1)CCCC2(CCCN(C2)C(=O)C3=CC=CC=C3)C4=CC(=C(C=C4)Cl)Cl)C5=CC=CC=C5
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InChIKeyDZOJBGLFWINFBF-UHFFFAOYSA-N
- Pubchem - Osanetant
- Wikipedia - osanetant
Osanetant (SR-142,801) was a neurokinin 3 receptor antagonist developed by Sanofi-Synthlabo, which was being researched for the treatment of schizophrenia, but was discontinued. It was the first non-peptide NK3 antagonist developed in the mid-1990s, Other potential applications for osanetant is in the treatment of drug addiction, as it has been found to block the effects of cocaine in animal models.
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