| Weight | 370.43 g/mol |
|---|---|
| Formula | C19H18N2O4S |
| Hydrogen Acceptors | 5 |
| Hydrogen Donors | 1 |
| Aromatic Rings | 3 |
| Rotatable Bonds | 5 |
Parecoxib (198470-84-7)
Score:
#691 in Neuroscience
,
#3087 in Biology
,
#3858 in Chemistry
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- Complications of the COX-2 Inhibitors Parecoxib and Valdecoxib after Cardiac Surgery (The New England Journal of Medicine, 2005)
- Efficacy and safety of the cyclooxygenase 2 inhibitors parecoxib and valdecoxib in patients undergoing coronary artery bypass surgery (The Journal of Thoracic and Cardiovascular Surgery, 2003)
- N-[[(5-methyl-3-phenylisoxazol-4-yl)-phenyl]sulfonyl]propanamide, sodium salt, parecoxib sodium: A potent and selective inhibitor of COX-2 for parenteral administration. (Journal of Medicinal Chemistry, 2000)
- Safety and efficacy of the cyclooxygenase-2 inhibitors parecoxib and valdecoxib after noncardiac surgery. (Anesthesiology, 2006)
- Efficacy and safety of intravenous parecoxib sodium in relieving acute postoperative pain following gynecologic laparotomy surgery. (Anesthesiology, 2002)
- The injectable cyclooxygenase-2-specific inhibitor parecoxib sodium has analgesic efficacy when administered preoperatively. (Anesthesia & Analgesia, 2001)
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SMILESCCC(=O)NS(=O)(=O)C1=CC=C(C=C1)C2=C(ON=C2C3=CC=CC=C3)C
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- Pubchem - Parecoxib
- Wikipedia - parecoxib
Parecoxib is a water-soluble and injectable prodrug of valdecoxib. It is marketed as Dynastat in the European Union. Parecoxib is a COX2 selective inhibitor in the same category as celecoxib (Celebrex) and rofecoxib (Vioxx).
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Synthesis
5-Methyl-3-phenylisoxazole-4-carboxylic acid
+
Reactant
(Decarboxylative coupling)
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Parecoxib
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