Weight | 403.441 g/mol |
---|---|
Formula | C17H13N3O5S2 |
Hydrogen Acceptors | 6 |
Hydrogen Donors | 3 |
Aromatic Rings | 3 |
Rotatable Bonds | 6 |
phthalylsulfathiazole (85-73-4)
ftalazol · phthalazol · phthalylsulfathiazole monosodium salt
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- The Diarrhea of Travelers: V. Prophylaxis with Phthalylsulfathiazole and Neomycin Sulphate (JAMA, 1962)
- The Clinical Use of Phthalylsulfathiazole. (Journal of Laboratory and Clinical Medicine, 1944)
- The Effect of Succinylsulfathiazole and Phthalylsulfathiazole on the Bacterial Flora of Rat Feces (Journal of Nutrition, 1945)
- PHTHALYLSULFATHIAZOLE (SULFATHALIDINE): CLINICAL, CHEMICAL AND BACTERIOLOGIC EVALUATIONS IN INFECTIOUS DISEASES OF THE COLON (JAMA, 1945)
- The effect of phthalylsulfathiazole (sulfathalidine) on the excretion of B-vitamins by normal adults. (Archives of Biochemistry and Biophysics, 1947)
- Calcium Oxalate Excretion and Hematuria in Vitamin B6-Deficient Rats Fed Phthalylsulfathiazole (Journal of Nutrition, 1959)
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Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. - ftalazol
- phthalazol
- phthalylsulfathiazole monosodium salt
-
SMILESC1=CC=C(C(=C1)C(=O)NC2=CC=C(C=C2)S(=O)(=O)NC3=NC=CS3)C(=O)O
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InChIKeyPBMSWVPMRUJMPE-UHFFFAOYSA-N
- Pubchem - phthalylsulfathiazole
- Wikipedia - phthalylsulfathiazole
Phthalylsulfathiazole belongs to the group of drugs called sulfonamides. The drug is a broad spectrum antimicrobial that can treat different types of infections including intestinal. The mechanism of action depends if based on competitive antagonism with para-aminobenzoic acid and inhibition of dihydropteroate synthetase activity, that in turn leads to impaired synthesis of dihydrofolic acid and as a result its active metabolite that is necessary for the synthesis of purine and pyrimidine.
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