| Weight | 351.41 g/mol |
|---|---|
| Formula | C19H21N5O2 |
| Hydrogen Acceptors | 5 |
| Hydrogen Donors | 1 |
| Aromatic Rings | 2 |
| Rotatable Bonds | 2 |
pirenzepine (28797-61-7)
L-S 519 · Dolorgiet Brand of Pirenzepine Dihydrochloride · ct-Arzneimittel Brand of Pirenzepine Dihydrochloride
Score:
#740 in Neuroscience
,
#3276 in Biology
,
#4090 in Chemistry
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- Pirenzepine distinguishes between different subclasses of muscarinic receptors. (Nature, 1980)
- A unique regulatory profile and regional distribution of [3H]pirenzepine binding in the rat provide evidence for distinct M1 and M2 muscarinic receptor subtypes (Life Sciences, 1983)
- Pirenzepine distinguishes between muscarinic receptor-mediated phosphoinositide breakdown and inhibition of adenylate cyclase. (Journal of Pharmacology and Experimental Therapeutics, 1985)
- [3H] pirenzepine selectively identifies a high affinity population of muscarinic cholinergic receptors in the rat cerebral cortex (Life Sciences, 1982)
- Comparison of [3H]pirenzepine and [3H]quinuclidinylbenzilate binding to muscarinic cholinergic receptors in rat brain. (Journal of Pharmacology and Experimental Therapeutics, 1984)
- Blockade of spatial learning by the M1 muscarinic antagonist pirenzepine (Psychopharmacology, 1987)
-
Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. - L-S 519
- Dolorgiet Brand of Pirenzepine Dihydrochloride
- ct-Arzneimittel Brand of Pirenzepine Dihydrochloride
- Pirenzepine Dihydrochloride
- Gastrozepin
- Piren basan
- Ulgescum
- LS-519
- LS 519
- Pirenzepin-ratiopharm
- Pirenzepin
- pirenzepin von ct
- LS519
- Gastrotsepin
- Pyrenzepine
- Boehringer Ingelheim Brand of Pirenzepine Dihydrochloride
- Pirenzepin ratiopharm
- Ulcoprotect
- Sagitta Brand of Pirenzepine Dihydrochloride
- Azupharma Brand of Pirenzepine Dihydrochloride
- ratiopharm Brand of Pirenzepine Dihydrochloride
- Piren-basan
-
SMILESCN1CCN(CC1)CC(=O)N2C3=CC=CC=C3C(=O)NC4=C2N=CC=C4
-
InChIKeyRMHMFHUVIITRHF-UHFFFAOYSA-N
- Pubchem - pirenzepine
- Wikipedia - pirenzepine
Pirenzepine (Gastrozepin), an M1 selective antagonist, is used in the treatment of peptic ulcers, as it reduces gastric acid secretion and reduces muscle spasm. It is in a class of drugs known as muscarinic receptor antagonists - acetylcholine being the neurotransmitter of the parasympathetic nervous system which initiates the rest-and-digest state (as opposed to fight-or-flight), resulting in an increase in gastric motility and digestion; whereas pirenzepine would inhibit these actions and cause decreased gastric motility leading to delayed gastric emptying and constipation. It has no effects on the brain and spinal cord as it cannot diffuse through the bloodbrain barrier.
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3 suppliers
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pirenzepine
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