| Weight | 373.953 g/mol |
|---|---|
| Formula | C20H24ClN3S |
| Hydrogen Acceptors | 4 |
| Hydrogen Donors | 0 |
| Aromatic Rings | 2 |
| Rotatable Bonds | 4 |
prochlorperazine (58-38-8, 84-02-6)
Compazine · Prochlorperazine Edisylate · Prochlorperazine Maleate
Score:
#26 in Neurology
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#130 in Neuroscience
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#635 in Biology
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#677 in Chemistry
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- Antiemetic Efficacy of High-Dose Metoclopramide: Randomized Trials with Placebo and Prochlorperazine in Patients with Chemotherapy-Induced Nausea and Vomiting (The New England Journal of Medicine, 1981)
- Antiemetics in patients receiving chemotherapy for cancer: a randomized comparison of delta-9-tetrahydrocannabinol and prochlorperazine. (The New England Journal of Medicine, 1980)
- Randomized, placebo-controlled evaluation of prochlorperazine versus metoclopramide for emergency department treatment of migraine headache (Annals of Emergency Medicine, 1995)
- Superiority of Nabilone over Prochlorperazine as an Antiemetic in Patients Receiving Cancer Chemotherapy (The New England Journal of Medicine, 1979)
- Antiemetic efficacy of dexamethasone. Randomized, double-blind, crossover study with prochlorperazine in patients receiving cancer chemotherapy. (The New England Journal of Medicine, 1984)
- Randomized Double-blind Trial of Intravenous Prochlorperazine for the Treatment of Acute Headache (JAMA, 1989)
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Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. - Compazine
- Prochlorperazine Edisylate
- Prochlorperazine Maleate
- Prochlorperazine Edisylate Salt
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SMILESCN1CCN(CC1)CCCN2C3=CC=CC=C3SC4=C2C=C(C=C4)Cl
-
InChIKeyWIKYUJGCLQQFNW-UHFFFAOYSA-N
- Pubchem - prochlorperazine
- Wikipedia - prochlorperazine
Prochlorperazine is a dopamine (D2) receptor antagonist that belongs to the phenothiazine class of antipsychotic agents that are used for the antiemetic treatment of nausea and vertigo. It is also a highly potent typical antipsychotic, 1020 times more potent than chlorpromazine. It is also used to treat migraine headaches.
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Estimated Properties
| Boiling Point | 337.55 C | EPA T.E.S.T. |
|---|---|---|
| Density | 1.23 g/cm3 | EPA T.E.S.T. |
| Flash Point | 268.29 C | EPA T.E.S.T. |
| Water Solubility | 8.14 mg/L | EPA T.E.S.T. |
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