| Weight | 253.737 g/mol |
|---|---|
| Formula | C11H16ClN5 |
| Hydrogen Acceptors | 1 |
| Hydrogen Donors | 3 |
| Aromatic Rings | 1 |
| Rotatable Bonds | 2 |
proguanil (500-92-5)
Paludrine · Chloroguanide · Proguanil Hydrochloride
Score:
#302 in Microbiology
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#2581 in Biology
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#3221 in Chemistry
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- Pyrimethamine and proguanil resistance-conferring mutations in Plasmodium falciparum dihydrofolate reductase: polymerase chain reaction methods for surveillance in Africa. (American Journal of Tropical Medicine and Hygiene, 1995)
- Transformation with human dihydrofolate reductase renders malaria parasites insensitive to WR99210 but does not affect the intrinsic activity of proguanil (Proceedings of the National Academy of Sciences of the United States of America, 1997)
- Acquired resistance to proguanil in Plasmodium vivax. (The Lancet, 1949)
- Atovaquone-Proguanil versus Mefloquine for Malaria Prophylaxis in Nonimmune Travelers: Results from a Randomized, Double-Blind Study (Clinical Infectious Diseases, 2001)
- A Mechanism for the Synergistic Antimalarial Action of Atovaquone and Proguanil (Antimicrobial Agents and Chemotherapy, 1999)
- Malarone (atovaquone and proguanil hydrochloride): a review of its clinical development for treatment of malaria. Malarone Clinical Trials Study Group. (American Journal of Tropical Medicine and Hygiene, 1999)
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Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. - Paludrine
- Chloroguanide
- Proguanil Hydrochloride
- Chloroguanide Hydrochloride
- Bigumal
- Chloriguane
- Paludrin
- Chlorguanid
-
SMILESCC(C)N=C(N)N=C(N)NC1=CC=C(C=C1)Cl
-
InChIKeySSOLNOMRVKKSON-UHFFFAOYSA-N
- Pubchem - proguanil
- Wikipedia - proguanil
Proguanil, also known as chlorguanide and chloroguanide, is a medication used to treat and prevent malaria. It is often used together with chloroquine or atovaquone. When used with chloroquine the combination will treat mild chloroquine resistant malaria.
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N'-Propan-2-ylmethanediimine
+
Reactant
(Thiourea)
Reactant
+
ISOPROPYLAMINE
(Imine formation from aldehyde)
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