| Weight | 326.48 g/mol |
|---|---|
| Formula | C22H30O2 |
| Hydrogen Acceptors | 2 |
| Hydrogen Donors | 0 |
| Aromatic Rings | 0 |
| Rotatable Bonds | 2 |
Promegestone (34184-77-5)
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- Progesterone and promegestone stimulate human bone cell proliferation and insulin-like growth factor-2 production. (European Journal of Endocrinology, 1992)
- The Steroid Promegestone Is a Noncompetitive Antagonist of theTorpedo Nicotinic Acetylcholine Receptor that Interacts with the Lipid-Protein Interface (Molecular Pharmacology, 1999)
- Promegestone (R5020) and mifepristone (RU486) both function as progestational agonists of human glycodelin gene expression in isolated human epithelial cells. (The Journal of Clinical Endocrinology and Metabolism, 1998)
- Transformation of estrone and estradiol in hormone-dependent and hormone-independent human breast cancer cells. Effects of the antiestrogen ICI 164,384, danazol, and promegestone (R-5020). (Breast Cancer Research and Treatment, 1995)
- Effect of the progestagen Promegestone (R-5020) on mRNA of the oestrone sulphatase in the MCF-7 human mammary cancer cells. (Anticancer Research, 1994)
- Human estrogen sulfotransferase (hEST1) activities and its mRNA in various breast cancer cell lines. Effect of the progestin, promegestone (R-5020) (The Journal of Steroid Biochemistry and Molecular Biology, 1998)
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Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. -
SMILESCCC(=O)C1(CCC2C1(CCC3=C4CCC(=O)C=C4CCC23)C)C
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- Pubchem - Promegestone
- Wikipedia - promegestone
Promegestone (INN) (brand name Surgestone), also known as 17,21-dimethyl-9-19-norprogesterone or 17,21-dimethyl-19-norpregna-4,9-diene-3,20-dione, is a progestin of the 19-norprogesterone group which was introduced in 1983 and is or has been marketed in France, Portugal, and Argentina. Indications include gynaecological conditions caused by luteal insufficiency, including premenopausal disorders, dysmenorrhea, and premenstrual syndrome. Promegestone has weak glucocorticoid activity, but does not bind to the androgen receptor or possess antimineralocorticoid activity.
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