Weight | 362.39 g/mol |
---|---|
Formula | C16H22N6O4 |
Hydrogen Acceptors | 5 |
Hydrogen Donors | 4 |
Aromatic Rings | 1 |
Rotatable Bonds | 6 |
protirelin
Thyrotropin Releasing Hormone · Thyrotropin Releasing Factor · Thyroliberin
117217-40-0, 24305-27-9, 11096-37-0
Score:
#711 in Neuroscience
,
#1288 in Biochemistry
,
#3158 in Biology
,
#3954 in Chemistry
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- Immunohistochemical support for three putative transmitters in one neuron: Coexistence of 5-hydroxytryptamine, substance p- and thyrotropin releasing hormone-like immunoreactivity in medullary neurons projecting to the spinal cord (Neuroscience, 1981)
- Thyrotropin-Releasing Hormone (The New England Journal of Medicine, 1982)
- EFFECTS OF THYROTROPIN-RELEASING HORMONE IN DEPRESSION (The Lancet, 1972)
- Serum thyrotropin response to thyrotropin-releasing hormone in psychiatric patients: a review. (American Journal of Psychiatry, 1982)
- Thyrotropin-releasing hormone (TRH): distribution in hypothalamic and extrahypothalamic brain tissues of mammalian and submammalian chordates (Endocrinology, 1974)
- The identity of chemical and hormonal properties of the thyrotropin releasing hormone and pyroglutamyl-histidyl-proline amide (Biochemical and Biophysical Research Communications, 1969)
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Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. - Thyrotropin Releasing Hormone
- Thyrotropin Releasing Factor
- Thyroliberin
- Thypinone
- Relefact TRH
- Abbott-38579
- Proterelin Tartrate Hydrate
- TRH Ferring
- Antepan
- Stimu-TSH
- Thyroliberin TRH Merck
- Thyrotropin-Releasing Hormone Tartrate
- Thyrotropin-Releasing Hormone
- Thyrotropin Releasing Hormone Tartrate
- Stimu TSH
- Proterelin Tartrate
- Abbott38579
- Abbott 38579
- StimuTSH
- TRH Prem
- Protirelin Tartrate (1:1)
- Thyrotropin-Releasing Factor
-
SMILESC1CC(N(C1)C(=O)C(CC2=CN=CN2)NC(=O)C3CCC(=O)N3)C(=O)N
-
InChIKeyXNSAINXGIQZQOO-UHFFFAOYSA-N
- Pubchem - protirelin
- Wikipedia - Thyrotropin-releasing hormone
Thyrotropin-releasing hormone (TRH), also called thyrotropin-releasing factor (TRF) or thyroliberin, is a releasing hormone, produced by the hypothalamus, that stimulates the release of thyrotropin (thyroid-stimulating hormone or TSH) and prolactin from the anterior pituitary. It is a tropic, tripeptidal hormone. TRH has been used clinically for the treatment of spinocerebellar degeneration and disturbance of consciousness in humans.
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Synthesis
Reactant
+
L-prolinamide
(Schotten-Baumann amide from acid)
L-Pyroglutamamide
+
Reactant
(Alkylation of primary amines)
imidazole
+
Reactant
(Friedel-Crafts alkylation)
Reactant
+
L-prolinamide
(Chan-Lam coupling reaction)
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