| Weight | 321.468 g/mol |
|---|---|
| Formula | C21H27N3 |
| Hydrogen Acceptors | 3 |
| Hydrogen Donors | 1 |
| Aromatic Rings | 3 |
| Rotatable Bonds | 4 |
Rimcazole (75859-04-0)
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- Evidence that the potential antipsychotic agent rimcazole (BW 234U) is a specific, competitive antagonist of sigma sites in brain (Life Sciences, 1986)
- Activation of the A10 mesolimbic system by the -receptor agonist (+)SKF 10,047 can be blocked by rimcazole, a novel putative antipsychotic (European Journal of Pharmacology, 1988)
- Probes for the dopamine transporter: New leads toward a cocaineabuse therapeuticA focus on analogues of benztropine and rimcazole (Medicinal Research Reviews, 2002)
- Regulation of sigma-receptors: high- and low-affinity agonist states, GTP shifts, and up-regulation by rimcazole and 1,3-Di(2-tolyl)guanidine. (Journal of Neurochemistry, 1989)
- Rimcazole analogs attenuate the convulsive effects of cocaine: correlation with binding to sigma receptors rather than dopamine transporters (Neuropharmacology, 2001)
- Structure-activity relationships at the monoamine transporters and receptors for a novel series of 9-[3-(cis-3,5-dimethyl-1- piperazinyl)propyl]carbazole (rimcazole) analogues (Journal of Medicinal Chemistry, 1999)
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SMILESCC1CN(CC(N1)C)CCCN2C3=CC=CC=C3C4=CC=CC=C42
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InChIKeyGUDVQJXODNJRIJ-UHFFFAOYSA-N
- Pubchem - Rimcazole
- Wikipedia - rimcazole
Rimcazole is an antagonist of the sigma receptor as well as a dopamine reuptake inhibitor. Sigma receptors are thought to be involved in the drug psychosis that can be induced by some drugs such as phencyclidine and cocaine, and rimcazole was originally researched as a potential antipsychotic with a different mechanism of action to traditional antipsychotic drugs. Trials proved inconclusive and rimcazole was not pursued for this application, but other sigma antagonists continue to be researched for a variety of potential applications.
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