Weight | 260.381 g/mol |
---|---|
Formula | C16H24N2O |
Hydrogen Acceptors | 2 |
Hydrogen Donors | 1 |
Aromatic Rings | 1 |
Rotatable Bonds | 7 |
ropinirole (91374-21-9)
Score:
#8 in Neurology
,
#66 in Neuroscience
,
#344 in Biology
,
#362 in Chemistry
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- A five-year study of the incidence of dyskinesia in patients with early Parkinson's disease who were treated with ropinirole or levodopa. (The New England Journal of Medicine, 2000)
- Slower progression of Parkinson's disease with ropinirole versus levodopa: The REAL-PET study (Annals of Neurology, 2003)
- Falling asleep at the wheel: Motor vehicle mishaps in persons taking pramipexole and ropinirole (Neurology, 1999)
- Ropinirole in the treatment of restless legs syndrome: results from the TREAT RLS 1 study, a 12 week, randomised, placebo controlled study in 10 European countries (Journal of Neurology, Neurosurgery, and Psychiatry, 2004)
- Ropinirole for the treatment of early Parkinson's disease (Neurology, 1997)
- De novo administration of ropinirole and bromocriptine induces less dyskinesia than Ldopa in the MPTPtreated marmoset (Movement Disorders, 1998)
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Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. -
SMILESCCCN(CCC)CCC1=C2CC(=O)NC2=CC=C1
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- Pubchem - ropinirole
- Wikipedia - ropinirole
Ropinirole (INN; trade names Requip, Repreve, Ronirol, Adartrel) is a dopamine agonist of the non-ergoline class of medications. It is manufactured by GlaxoSmithKline (GSK), Cipla, Dr. Reddy's Laboratories and Sun Pharmaceutical.
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Areas of Application
Safety
Alternate Names
Estimated Properties
Boiling Point | 344.49 C | EPA T.E.S.T. |
---|---|---|
Density | 1.09 g/cm3 | EPA T.E.S.T. |
Flash Point | 217.71 C | EPA T.E.S.T. |
Water Solubility | 142.06 mg/L | EPA T.E.S.T. |
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Synthesis
Reactant
+
3-(2-(dipropylamino)ethyl)-2-methylaniline
(Schotten-Baumann amide from acid)
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