| Weight | 493.553 g/mol |
|---|---|
| Formula | C25H35NO9 |
| Hydrogen Acceptors | 9 |
| Hydrogen Donors | 7 |
| Aromatic Rings | 1 |
| Rotatable Bonds | 3 |
Ryania (15662-33-6)
Ryanodine
Score:
#1001 in Neuroscience
,
#2132 in Biochemistry
,
#4379 in Biology
,
#5536 in Chemistry
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- PKA Phosphorylation Dissociates FKBP12.6 from the Calcium Release Channel (Ryanodine Receptor): Defective Regulation in Failing Hearts (Cell, 2000)
- Identification of a mutation in porcine ryanodine receptor associated with malignant hyperthermia (Science, 1991)
- Mutations in the Cardiac Ryanodine Receptor Gene (hRyR2) Underlie Catecholaminergic Polymorphic Ventricular Tachycardia (Circulation, 2001)
- Activation of the Cardiac Calcium Release Channel (Ryanodine Receptor) by Poly-S-Nitrosylation (Science, 1998)
- Primary structure and expression from complementary DNA of skeletal muscle ryanodine receptor (Nature, 1989)
- Ryanodine Receptor Calcium Release Channels (Physiological Reviews, 2002)
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Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. - H302: Harmful if swallowed
Warning Acute toxicity, oral - Category 4 - H400: Very toxic to aquatic life
Warning Hazardous to the aquatic environment, acute hazard - Category 1 - H410: Very toxic to aquatic life with long lasting effects
Warning Hazardous to the aquatic environment, long-term hazard - Category 1 - Ryanodine
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SMILESCC1CCC2(C3(CC4(C5(C(C(C3(C5(C2(C1O)O4)O)O)OC(=O)C6=CC=CN6)(C(C)C)O)C)O)C)O
-
InChIKeyJJSYXNQGLHBRRK-UHFFFAOYSA-N
- Pubchem - Ryania
- Wikipedia - Ryanodine
Ryanodine is a poisonous diterpenoid found in the South American plant Ryania speciosa (Salicaceae). It was originally used as an insecticide. The compound has extremely high affinity to the open-form ryanodine receptor, a group of calcium channels found in skeletal muscle, smooth muscle, and heart muscle cells.
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