| Weight | 643.803 g/mol |
|---|---|
| Formula | C33H45N3O8S |
| Hydrogen Acceptors | 9 |
| Hydrogen Donors | 1 |
| Aromatic Rings | 2 |
| Rotatable Bonds | 10 |
Satavaptan (185913-78-4)
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- Effects of satavaptan, a selective vasopressin V2 receptor antagonist, on ascites and serum sodium in cirrhosis with hyponatremia: A randomized trial (Hepatology, 2008)
- Successful Long-Term Treatment of Hyponatremia in Syndrome of Inappropriate Antidiuretic Hormone Secretion with Satavaptan (SR121463B), an Orally Active Nonpeptide Vasopressin V2-Receptor Antagonist (Clinical Journal of The American Society of Nephrology, 2006)
- Satavaptan for the management of ascites in cirrhosis: efficacy and safety across the spectrum of ascites severity (Gut, 2012)
- Effects of a selective vasopressin V2 receptor antagonist, satavaptan, on ascites recurrence after paracentesis in patients with cirrhosis (Journal of Hepatology, 2010)
- Meta-analysis: the safety and efficacy of vaptans (tolvaptan, satavaptan and lixivaptan) in cirrhosis with ascites or hyponatraemia. (Alimentary Pharmacology & Therapeutics, 2012)
- Clinical trial: short-term effects of combination of satavaptan, a selective vasopressin V2 receptor antagonist, and diuretics on ascites in patients with cirrhosis without hyponatraemia a randomized, double-blind, placebo-controlled study (Alimentary Pharmacology & Therapeutics, 2010)
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SMILESCCOC1=CC2=C(C=C1)N(C(=O)C23CCC(CC3)OCCN4CCOCC4)S(=O)(=O)C5=C(C=C(C=C5)C(=O)NC(C)(C)C)OC
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- Pubchem - Satavaptan
- Wikipedia - Satavaptan
Satavaptan (INN; developmental code name SR121463, former tentative brand name Aquilda) is a vasopressin-2 receptor antagonist which was investigation by Sanofi-Aventis and was under development for the treatment of hyponatremia. It was also being studied for the treatment of ascites. Development was discontinued in 2009.
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