Weight | 401.506 g/mol |
---|---|
Formula | C26H27NO3 |
Hydrogen Acceptors | 3 |
Hydrogen Donors | 0 |
Aromatic Rings | 3 |
Rotatable Bonds | 8 |
Sch-48461 (148260-92-8)
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SMILESCOC1=CC=C(C=C1)C2C(C(=O)N2C3=CC=C(C=C3)OC)CCCC4=CC=CC=C4
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InChIKeyIMNTVVOUWFPRSB-UHFFFAOYSA-N
- Pubchem - Sch-48461
- Wikipedia - sch-48461
SCH-48461 is a cholesterol absorption inhibitor. During the early phases of an NPC1L1 inhibitor discovery program at Schering-Plough, conformationally restricted analogs based on the 2-azetidinone backbone were targeted by Burnett and co-workers. Early in the biological evaluation, it became apparent that even though the in vitro ACAT inhibitory activity of these analogs was modest (e.g., IC50 values of 250 mM), they exhibited significant activity in a cholesterol-fed hamster model (CFH).
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