| Weight | 223.165 g/mol |
|---|---|
| Formula | C7H14NO5P |
| Hydrogen Acceptors | 3 |
| Hydrogen Donors | 4 |
| Aromatic Rings | 0 |
| Rotatable Bonds | 3 |
Selfotel (113229-62-2, 110347-85-8)
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- Selfotel in Acute Ischemic Stroke Possible Neurotoxic Effects of an NMDA Antagonist (Stroke, 2000)
- Failure of the competitive N-methyl-d-aspartate antagonist Selfotel (CGS 19755) in the treatment of severe head injury: results of two Phase III clinical trials (Journal of Neurosurgery, 1999)
- Safety and Tolerability of the Glutamate Antagonist CGS 19755 (Selfotel) in Patients With Acute Ischemic Stroke Results of a Phase IIa Randomized Trial (Stroke, 1995)
- Termination of Acute Stroke Studies Involving Selfotel Treatment (The Lancet, 1997)
- Dose escalation safety and tolerance study of the competitive NMDA antagonist selfotel (CGS 19755) in neurosurgery patients. (Clinical Neuropharmacology, 1998)
- Catalytic asymmetric synthesis of cyclic amino acids and alkaloid derivatives: application to (+)-dihydropinidine and Selfotel synthesis (Chemical Science, 2010)
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- Pubchem - Selfotel
- Wikipedia - selfotel
Selfotel (CGS-19755) is a drug which acts as a competitive NMDA antagonist, directly competing with glutamate for binding to the receptor. Initial studies showed it to have anticonvulsant, anxiolytic, analgesic and neuroprotective effects, and it was originally researched for the treatment of stroke, but subsequent animal and human studies showed phencyclidine-like effects, as well as limited efficacy and evidence for possible neurotoxicity under some conditions, and so clinical development was ultimately discontinued.
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