| Weight | 354.446 g/mol |
|---|---|
| Formula | C22H26O4 |
| Hydrogen Acceptors | 3 |
| Hydrogen Donors | 1 |
| Aromatic Rings | 1 |
| Rotatable Bonds | 8 |
SERATRODAST (112665-43-7)
AA-2414 · AA 2414 · 7-(3,5,6-trimethyl-1,4-benzoquinon-2-yl)-7-phenylheptanoic acid
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- Effect of a thromboxane A2 receptor antagonist (AA-2414) on bronchial hyperresponsiveness to methacholine in subjects with asthma (The Journal of Allergy and Clinical Immunology, 1991)
- A novel anti-asthmatic quinone derivative, AA-2414 with a potent antagonistic activity against a variety of spasmogenic prostanoids (Prostaglandins, 1989)
- Effect of AA-2414, a thromboxane A2 receptor antagonist, on airway inflammation in subjects with asthma (The Journal of Allergy and Clinical Immunology, 1999)
- Antagonism of the Human Thromboxane A2 Receptor by an Anti-asthmatic Agent AA-2414 (Biological & Pharmaceutical Bulletin, 1994)
- Identification of Cytochromes P450 Involved in the Human Liver Microsomal Metabolism of the Thromboxane A2 Inhibitor Seratrodast (ABT-001) (Drug Metabolism and Disposition, 1997)
- Antagonistic action of AA-2414 on thromboxane A2/prostaglandin endoperoxide receptor in platelets and blood vessels (Japanese Journal of Pharmacology, 1990)
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Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. - AA-2414
- AA 2414
- 7-(3,5,6-trimethyl-1,4-benzoquinon-2-yl)-7-phenylheptanoic acid
- ABT-001
-
SMILESCC1=C(C(=O)C(=C(C1=O)C)C(CCCCCC(=O)O)C2=CC=CC=C2)C
-
InChIKeyZBVKEHDGYSLCCC-UHFFFAOYSA-N
- Pubchem - SERATRODAST
- Wikipedia - seratrodast
Seratrodast (development name, AA-2414; marketed originally as Bronica) is a thromboxane A2 (TXA2) receptor (TP receptor) antagonist used primarily in the treatment of asthma. It was the first TP receptor antagonist that was developed as an anti-asthmatic drug and received marketing approval in Japan in 1997. As of 2017 seratrodast was marketed as Bronica in Japan, and as Changnuo, Mai Xu Jia, Quan Kang Nuo in China.
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Synthesis
benzene
+
Reactant
(Friedel-Crafts alkylation)
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SERATRODAST
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