| Weight | 329.396 g/mol |
|---|---|
| Formula | C19H23NO4 |
| Hydrogen Acceptors | 5 |
| Hydrogen Donors | 1 |
| Aromatic Rings | 1 |
| Rotatable Bonds | 2 |
Sinomenine (115-53-7)
cucoline hydrochloride · cucoline, hydrochloride · cocculine
Score:
#1112 in Neuroscience
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#2466 in Biochemistry
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#4828 in Biology
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#6164 in Chemistry
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- AMELIORATION OF RAT EXPERIMENTAL ARTHRITIDES BY TREATMENT WITH THE ALKALOID SINOMENINE (International Journal of Immunopharmacology, 1996)
- Sinomenine, a natural dextrorotatory morphinan analog, is anti-inflammatory and neuroprotective through inhibition of microglial NADPH oxidase (Journal of Neuroinflammation, 2007)
- Pharmacology of sinomenine, an anti-rheumatic alkaloid from Sinomenium acutum. (Acta Medica Okayama, 1976)
- Effect of sinomenine on cytokine expression of macrophages and synoviocytes in adjuvant arthritis rats (Journal of Ethnopharmacology, 2005)
- Inhibition of lymphocyte proliferation by the anti-arthritic drug sinomenine. (International Journal of Immunopharmacology, 1994)
- Sinomenine Versus NSAIDs for the Treatment of Rheumatoid Arthritis: A Systematic Review and Meta-Analysis (Planta Medica, 2008)
-
Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. - cucoline hydrochloride
- cucoline, hydrochloride
- cocculine
- morphinan-6-one, 7,8-didehydro-4-hydroxy-3,7-dimethoxy-17-methyl-, (9alpha,13alpha,14alpha)-
- sinomenine A bismethyliodide
- cuculine
- morphinan-6-one, 7,8-didehydro-4-hydroxy-3,7-dimethoxy-17-methyl-, hydrochloride (1:1), (9alpha,13alpha,14alpha)-
- cucoline
- NSC-7601
- kukoline
- 4-hydroxy-3,7-dimethoxy-17-methylmorphin-7-en- 6-one
- sinomenin hydrochloride
- sinomenine hydrochloride
-
SMILESCN1CCC23CC(=O)C(=CC2C1CC4=C3C(=C(C=C4)OC)O)OC
-
InChIKeyINYYVPJSBIVGPH-UHFFFAOYSA-N
- Pubchem - Sinomenine
- Wikipedia - sinomenine
Sinomenine or cocculine is an alkaloid found in the root of the climbing plant Sinomenium acutum which is native to Japan and China. It is traditionally used in herbal medicine in these countries, as a treatment for rheumatism and arthritis. However, its analgesic action against other kinds of pain is limited.
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Sinomenine
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