| Weight | 362.473 g/mol |
|---|---|
| Formula | C23H26N2O2 |
| Hydrogen Acceptors | 3 |
| Hydrogen Donors | 0 |
| Aromatic Rings | 2 |
| Rotatable Bonds | 2 |
Solifenacin (242478-37-1)
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- Randomized, double-blind placebo- and tolterodine-controlled trial of the once-daily antimuscarinic agent solifenacin in patients with symptomatic overactive bladder (BJUI, 2004)
- A comparison of the efficacy and tolerability of solifenacin succinate and extended release tolterodine at treating overactive bladder syndrome: results of the STAR trial. (European Urology, 2005)
- RANDOMIZED, DOUBLE-BLIND PLACEBO CONTROLLED TRIAL OF THE ONCE DAILY ANTIMUSCARINIC AGENT SOLIFENACIN SUCCINATE IN PATIENTS WITH OVERACTIVE BLADDER (The Journal of Urology, 2004)
- M3 receptor antagonism by the novel antimuscarinic agent solifenacin in the urinary bladder and salivary gland (Naunyn-schmiedebergs Archives of Pharmacology, 2002)
- Solifenacin appears effective and well tolerated in patients with symptomatic idiopathic detrusor overactivity in a placebo and tolterodinecontrolled phase 2 dosefinding study (BJUI, 2004)
- Efficacy and tolerability of solifenacin in elderly subjects with overactive bladder syndrome: A pooled analysis (American Journal of Geriatric Pharmacotherapy, 2006)
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Predict GHS Hazards for Any Chemical in silico.
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SMILESC1CN2CCC1C(C2)OC(=O)N3CCC4=CC=CC=C4C3C5=CC=CC=C5
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InChIKeyFBOUYBDGKBSUES-UHFFFAOYSA-N
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Synthesis
(R)-Quinuclidin-3-yl chloroformate
+
1-Phenyl-1,2,3,4-tetrahydroisoquinoline
(Schotten-Baumann amide from acid)
benzene
+
Reactant
(Friedel-Crafts alkylation)
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