| Weight | 173.212 g/mol |
|---|---|
| Formula | C8H15NO3 |
| Hydrogen Acceptors | 4 |
| Hydrogen Donors | 3 |
| Aromatic Rings | 0 |
| Rotatable Bonds | 0 |
swainsonine (72741-87-8)
Score:
#1681 in Biochemistry
,
#3765 in Biology
,
#4741 in Chemistry
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- Swainsonine inhibits the biosynthesis of complex glycoproteins by inhibition of Golgi mannosidase II. (Journal of Biological Chemistry, 1982)
- A Spectroscopic Investigation of Swainsonine: an a-Mannosidase Inhibitor Isolated from Swainsona canescens (Australian Journal of Chemistry, 1979)
- Inhibition of lysosomal alpha-mannosidase by swainsonine, an indolizidine alkaloid isolated from Swainsona canescens. (Biochemical Journal, 1980)
- Effects of swainsonine and polyinosinic:polycytidylic acid on murine tumor cell growth and metastasis. (Cancer Research, 1986)
- Swainsonine: an inhibitor of glycoprotein processing (Proceedings of the National Academy of Sciences of the United States of America, 1981)
- Phase IB clinical trial of the oligosaccharide processing inhibitor swainsonine in patients with advanced malignancies. (Clinical Cancer Research, 1997)
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Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. -
SMILESC1CC(C2C(C(CN2C1)O)O)O
-
InChIKeyFXUAIOOAOAVCGD-UHFFFAOYSA-N
- Pubchem - swainsonine
- Wikipedia - tridolgosir
Swainsonine is an indolizidine alkaloid. It is a potent inhibitor of Golgi alpha-mannosidase II, an immunomodulator, and a potential chemotherapy drug. As a toxin in locoweed (likely its primary toxin) it also is a significant cause of economic losses in livestock industries, particularly in North America.
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