| Weight | 372.373 g/mol |
|---|---|
| Formula | C20H20O7 |
| Hydrogen Acceptors | 7 |
| Hydrogen Donors | 0 |
| Aromatic Rings | 3 |
| Rotatable Bonds | 6 |
Tangeretin (481-53-8)
tangeritin · 4',5,6,7,8-pentamethoxyflavone · 4',5,6,7,8-pentamethoxy-flavone
Score:
#2014 in Biochemistry
,
#4223 in Biology
,
#5323 in Chemistry
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- Citrus flavone tangeretin inhibits leukaemic HL-60 cell growth partially through induction of apoptosis with less cytotoxicity on normal lymphocytes (British Journal of Cancer, 1995)
- Tissue distribution and neuroprotective effects of citrus flavonoid tangeretin in a rat model of Parkinson's disease. (Neuroreport, 2001)
- Tangeretin induces cell-cycle G1 arrest through inhibiting cyclin-dependent kinases 2 and 4 activities as well as elevating Cdk inhibitors p21 and p27 in human colorectal carcinoma cells (Carcinogenesis, 2002)
- Tangeretin and nobiletin induce G1 cell cycle arrest but not apoptosis in human breast and colon cancer cells (Cancer Letters, 2007)
- Tangeretin suppresses IL-1-induced cyclooxygenase (COX)-2 expression through inhibition of p38 MAPK, JNK, and AKT activation in human lung carcinoma cells (Biochemical Pharmacology, 2007)
- Tangeretin sensitizes cisplatin-resistant human ovarian cancer cells through downregulation of phosphoinositide 3-kinase/akt signaling pathway. (Cancer Research, 2009)
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Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. - tangeritin
- 4',5,6,7,8-pentamethoxyflavone
- 4',5,6,7,8-pentamethoxy-flavone
-
SMILESCOC1=CC=C(C=C1)C2=CC(=O)C3=C(O2)C(=C(C(=C3OC)OC)OC)OC
-
InChIKeyULSUXBXHSYSGDT-UHFFFAOYSA-N
- Pubchem - Tangeretin
- Wikipedia - tangeretin
Tangeretin is an O-polymethoxylated flavone that is found in tangerine and other citrus peels. Tangeretin strengthens the cell wall and acts as a plant's defensive mechanism against disease-causing pathogens. It has also been used as a marker compound to detect contamination in citrus juices.
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