| Weight | 275.442 g/mol |
|---|---|
| Formula | C15H17NS2 |
| Hydrogen Acceptors | 3 |
| Hydrogen Donors | 0 |
| Aromatic Rings | 2 |
| Rotatable Bonds | 2 |
Tipepidine (5169-78-8)
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- The centrally acting non-narcotic antitussive tipepidine produces antidepressant-like effect in the forced swimming test in rats. (Behavioural Brain Research, 2009)
- Pharmacological mechanisms of antidepressant-like effect of tipepidine in the forced swimming test. (Behavioural Brain Research, 2012)
- Tipepidine activates VTA dopamine neuron via inhibiting dopamine D2 receptor-mediated inward rectifying K+ current (Neuroscience, 2013)
- The potent inhibitory effect of tipepidine on marble-burying behavior in mice. (Behavioural Brain Research, 2011)
- Effect of tipepidine with novel antidepressant-like action on c-fos-like protein expression in rat brain. (Brain Research, 2013)
- Tipepidine in children with attention deficit/hyperactivity disorder: a 4-week, open-label, preliminary study. (Neuropsychiatric Disease and Treatment, 2014)
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SMILESCN1CCCC(=C(C2=CC=CS2)C3=CC=CS3)C1
-
InChIKeyJWIXXNLOKOAAQT-UHFFFAOYSA-N
- Pubchem - Tipepidine
- Wikipedia - tipepidine
Tipepidine (INN) (brand names Asverin, Antupex, Asvelik, Asvex, Bitiodin, Cofdenin A, Hustel, Nodal, Sotal), also known as tipepidine hibenzate (JAN), is a synthetic, non-opioid antitussive and expectorant of the thiambutene class. It acts as an inhibitor of G protein-coupled inwardly-rectifying potassium channels (GIRKs). The drug was discovered in the 1950s, and was developed in Japan in 1959.
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