| Weight | 416.359 g/mol |
|---|---|
| Formula | C20H15F3N4O3 |
| Hydrogen Acceptors | 6 |
| Hydrogen Donors | 2 |
| Aromatic Rings | 3 |
| Rotatable Bonds | 3 |
Trovafloxacin (147059-72-1)
Score:
#385 in Microbiology
,
#2999 in Biology
,
#3747 in Chemistry
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- Comparison of the antibacterial activities of the quinolones Bay 12-8039, gatifloxacin (AM 1155), trovafloxacin, clinafloxacin, levofloxacin and ciprofloxacin. (Journal of Antimicrobial Chemotherapy, 1997)
- Separation of levofloxacin, ciprofloxacin, gatifloxacin, moxifloxacin, trovafloxacin and cinoxacin by high-performance liquid chromatography: application to levofloxacin determination in human plasma. (Journal of Chromatography B, 2002)
- Comparative Pharmacokinetics of Ciprofloxacin, Gatifloxacin, Grepafloxacin, Levofloxacin, Trovafloxacin, and Moxifloxacin after Single Oral Administration in Healthy Volunteers (Antimicrobial Agents and Chemotherapy, 2000)
- The chemistry and biological profile of trovafloxacin (Journal of Antimicrobial Chemotherapy, 1997)
- Activity of the new fluoroquinolone trovafloxacin (CP-99,219) against DNA gyrase and topoisomerase IV mutants of Streptococcus pneumoniae selected in vitro. (Antimicrobial Agents and Chemotherapy, 1996)
- Lipopolysaccharide and Trovafloxacin Coexposure in Mice Causes Idiosyncrasy-Like Liver Injury Dependent on Tumor Necrosis Factor-Alpha (Toxicological Sciences, 2007)
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Predict GHS Hazards for Any Chemical in silico.
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- Pubchem - Trovafloxacin
- Wikipedia - Trovafloxacin
Trovafloxacin (sold as Trovan by Pfizer and Turvel by Laboratorios Almirall) was a broad spectrum antibiotic that inhibits the uncoiling of supercoiled DNA in various bacteria by blocking the activity of DNA gyrase and topoisomerase IV. It was withdrawn from the market due to the risk of hepatotoxicity. It had better Gram-positive bacterial coverage and less Gram-negative coverage than the previous fluoroquinolones.
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