| Weight | 252.101 g/mol |
|---|---|
| Formula | C8H11Cl2N3O2 |
| Hydrogen Acceptors | 3 |
| Hydrogen Donors | 2 |
| Aromatic Rings | 1 |
| Rotatable Bonds | 5 |
URACIL MUSTARD (66-75-1)
5-(Bis(2-chloroethyl)amino)-2,4-(1H,3H)pyrimidinedione · Uramustine
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- Inhibitory effects of 5-(2-pyrazinyl)-4-methyl-1,2-dithioI-3-thione (Oltipraz) on carcinogenesis induced by benzo[a]pyrene, diethylnitrosamine and uracil mustard (Carcinogenesis, 1986)
- Design, synthesis, and biological activity of hybrid compounds between uramustine and DNA minor groove binder distamycin A. (Journal of Medicinal Chemistry, 2002)
- Effect of Uracil Mustard and Several Antitumor Drugs on the Primary Antibody Response in Rats and Mice (Journal of the National Cancer Institute, 1965)
- Pulmonary toxicity recurring after a six week course of busulfan therapy and after subsequent therapy with uracil mustard. (Chest, 1978)
- Acute leukemia following treatment of polycythemia vera and essential thrombocythemia with uracil mustard (American Journal of Hematology, 1988)
- Uracil Mustard: A Potent Inducer of Lung Tumors in Mice (Science, 1965)
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Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. - 5-(Bis(2-chloroethyl)amino)-2,4-(1H,3H)pyrimidinedione
- Uramustine
-
SMILESC1=C(C(=O)NC(=O)N1)N(CCCl)CCCl
-
InChIKeyIDPUKCWIGUEADI-UHFFFAOYSA-N
- Pubchem - URACIL MUSTARD
- Wikipedia - uracil mustard
Uramustine (INN) or uracil mustard is a chemotherapy drug which belongs to the class of alkylating agents. It is used in lymphatic malignancies such as non-Hodgkin's lymphoma. It works by damaging DNA, primarily in cancer cells that preferentially take up the uracil due to their need to make nucleic acids during their rapid cycles of cell division.
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