| Weight | 380.4 g/mol |
|---|---|
| Formula | C21H20N2O5 |
| Hydrogen Acceptors | 5 |
| Hydrogen Donors | 2 |
| Aromatic Rings | 3 |
| Rotatable Bonds | 8 |
Varespladib (172732-68-2)
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- Varespladib and Cardiovascular Events in Patients With an Acute Coronary Syndrome The VISTA-16 Randomized Clinical Trial (JAMA, 2014)
- Varespladib (A-002), a secretory phospholipase A2 inhibitor, reduces atherosclerosis and aneurysm formation in ApoE-/- mice. (Journal of Cardiovascular Pharmacology, 2009)
- The synergistic inhibition of atherogenesis in apoE/ mice between pravastatin and the sPLA2 inhibitor varespladib (A-002) (Journal of Lipid Research, 2009)
- Effects of Varespladib Methyl on Biomarkers and Major Cardiovascular Events in Acute Coronary Syndrome Patients (Journal of the American College of Cardiology, 2010)
- A-002 (Varespladib), a phospholipase A2 inhibitor, reduces atherosclerosis in guinea pigs (BMC Cardiovascular Disorders, 2009)
- Varespladib methyl in cardiovascular disease. (Expert Opinion on Investigational Drugs, 2010)
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SMILESCCC1=C(C2=C(N1CC3=CC=CC=C3)C=CC=C2OCC(=O)O)C(=O)C(=O)N
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- Pubchem - Varespladib
- Wikipedia - varespladib
Varespladib is an inhibitor of the IIa, V, and X isoforms of secretory phospholipase A2 (sPLA2). The molecule acts as an anti-inflammatory agent by disrupting the first step of the arachidonic acid pathway of inflammation. From 2006 to 2012, varespladib was under active investigation by Anthera Pharmaceuticals as a potential therapy for several inflammatory diseases, including acute coronary syndrome and acute chest syndrome.
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Varespladib
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