| Weight | 824.972 g/mol |
|---|---|
| Formula | C46H56N4O10 |
| Hydrogen Acceptors | 12 |
| Hydrogen Donors | 3 |
| Aromatic Rings | 3 |
| Rotatable Bonds | 8 |
vincristine (57-22-7)
Oncovin · Vincristine Sulfate · Leurocristine
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#145 in Neuroscience
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#707 in Biology
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- Overcoming of Vincristine Resistance in P388 Leukemia in Vivo and in Vitro through Enhanced Cytotoxicity of Vincristine and Vinblastine by Verapamil (Cancer Research, 1981)
- Frontline therapy with rituximab added to the combination of cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) significantly improves the outcome for patients with advanced-stage follicular lymphoma compared with therapy with CHOP alone: results of a prospective randomized study of the German Low-Grade Lymphoma Study Group (Blood, 2005)
- Topotecan versus cyclophosphamide, doxorubicin, and vincristine for the treatment of recurrent small-cell lung cancer. (Journal of Clinical Oncology, 1999)
- Adjuvant procarbazine, lomustine, and vincristine improves progression-free survival but not overall survival in newly diagnosed anaplastic oligodendrogliomas and oligoastrocytomas: a randomized European Organisation for Research and Treatment of Cancer phase III trial. (Journal of Clinical Oncology, 2006)
- Increased Accumulation of Vincristine and Adriamycin in Drug-resistant P388 Tumor Cells following Incubation with Calcium Antagonists and Calmodulin Inhibitors (Cancer Research, 1982)
- NOA-04 Randomized Phase III Trial of Sequential Radiochemotherapy of Anaplastic Glioma With Procarbazine, Lomustine, and Vincristine or Temozolomide (Journal of Clinical Oncology, 2009)
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Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. - Oncovin
- Vincristine Sulfate
- Leurocristine
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SMILESCCC1(CC2CC(C3=C(CCN(C2)C1)C4=CC=CC=C4N3)(C5=C(C=C6C(=C5)C78CCN9C7C(C=CC9)(C(C(C8N6C=O)(C(=O)OC)O)OC(=O)C)CC)OC)C(=O)OC)O
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- Pubchem - vincristine
- Wikipedia - vincristine
Vincristine, also known as leurocristine and marketed under the brandname Oncovin among others, is a chemotherapy medication used to treat a number of types of cancer. This includes acute lymphocytic leukemia, acute myeloid leukemia, Hodgkin's disease, neuroblastoma, and small cell lung cancer among others. It is given intravenously.
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