| Weight | 816.943 g/mol |
|---|---|
| Formula | C45H54F2N4O8 |
| Hydrogen Acceptors | 11 |
| Hydrogen Donors | 2 |
| Aromatic Rings | 3 |
| Rotatable Bonds | 7 |
Vinflunine (162652-95-1)
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- Phase III Trial of Vinflunine Plus Best Supportive Care Compared With Best Supportive Care Alone After a Platinum-Containing Regimen in Patients With Advanced Transitional Cell Carcinoma of the Urothelial Tract (Journal of Clinical Oncology, 2009)
- A phase II study of vinflunine in bladder cancer patients progressing after first-line platinum-containing regimen. (British Journal of Cancer, 2006)
- Vinflunine, the latest Vinca alkaloid in clinical development: A review of its preclinical anticancer properties (Critical Reviews in Oncology Hematology, 2001)
- Antimitotic and tubulin-interacting properties of vinflunine, a novel fluorinated Vinca alkaloid (Biochemical Pharmacology, 1998)
- Mechanism of Mitotic Block and Inhibition of Cell Proliferation by the Semisynthetic Vinca Alkaloids Vinorelbine and Its Newer Derivative Vinflunine (Molecular Pharmacology, 2001)
- Preclinical in vivo antitumor activity of vinflunine, a novel fluorinated Vinca alkaloid (Cancer Chemotherapy and Pharmacology, 1998)
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SMILESCCC12C=CCN3C1C4(CC3)C(C(C2OC(=O)C)(C(=O)OC)O)N(C5=CC(=C(C=C45)C6(CC7CC(CN(C7)CC8=C6NC9=CC=CC=C89)C(C)(F)F)C(=O)OC)OC)C
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InChIKeyNMDYYWFGPIMTKO-UHFFFAOYSA-N
- Pubchem - Vinflunine
- Wikipedia - Vinflunine
Vinflunine (INN, trade name Javlor) is a novel fluorinated vinca alkaloid derivative undergoing research for the treatment of bladder cancer. It was originally discovered by the team of the Professor Jean-Claude Jacquesy (UMR CNRS 6514 - Poitiers University), developed by Laboratoires Pierre Fabre and was licensed to Bristol-Myers Squibb for development in certain countries, including the United States. On November 23, 2007, Pierre Fabre Medicament and Bristol-Myers Squibb announced that they were terminating their license agreement for the development of vinflunine, and that Pierre Fabre were continuing "discussions with regulatory authorities and plan to file for the registration of vinflunine for bladder cancer in the first quarter of 2008." As of 2016, vinflunine is the only commercially-approved agent in some countries for salvage therapy of urothelial carcinoma, (with approval based on the results of a phase III trial), with a reported median OS of about 6 months.
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