Weight | 339.392 g/mol |
---|---|
Formula | C16H25N3O5 |
Hydrogen Acceptors | 6 |
Hydrogen Donors | 4 |
Aromatic Rings | 1 |
Rotatable Bonds | 8 |
Xamoterol (81801-12-9, 73210-73-8)
Corwin · Carwin · Xamoterol Hemifumarate
Score:
#4496 in Biology
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- Xamoterol in severe heart failure (The Lancet, 1990)
- Xamoterol Versus Digoxin in Heart-failure (The Lancet, 1988)
- DOUBLE-BLIND PLACEBO-CONTROLLED COMPARISON OF DIGOXIN AND XAMOTEROL IN CHRONIC HEART FAILURE (The Lancet, 1988)
- Effects of atenolol, verapamil, and xamoterol on heart rate and exercise tolerance in digitalised patients with chronic atrial fibrillation (Journal of Cardiovascular Pharmacology, 1989)
- Comprehensive Behavioral Phenotyping of Ts65Dn Mouse Model of Down Syndrome: Activation of 1-Adrenergic Receptor by Xamoterol as a Potential Cognitive Enhancer (Neurobiology of Disease, 2011)
- Effects of a Cardioselective Beta-1 Partial Agonist (corwin) On Left-ventricular Function and Myocardial-metabolism in Patients With Previous Myocardial-infarction (American Journal of Cardiology, 1983)
-
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. - Corwin
- Carwin
- Xamoterol Hemifumarate
- ICI 118587
- Xamoterol Maleate (2:1)
- Xamtol
- Xamoterol, (S)-Isomer
- ICI-118587
- ICI118587
- Xamoterol Monohydrochloride
- Xamoterol Monohydrobromide
- Xamoterol Fumarate
-
SMILESC1COCCN1C(=O)NCCNCC(COC2=CC=C(C=C2)O)O
-
InChIKeyDXPOSRCHIDYWHW-UHFFFAOYSA-N
- Pubchem - Xamoterol
- Wikipedia - xamoterol
Xamoterol is a cardiac stimulant. It works by binding to the 1 adrenergic receptor. It is a 3rd generation adrenergic receptor partial agonist.
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Synthesis
morpholine-4-carbonyl chloride
+
Reactant
(Schotten-Baumann amide from acid)
Reactant
+
Morpholine
(Thiourea)
Reactant
+
SCHEMBL6074194
(Reductive amination)
Hydroquinone
+
Reactant
(Williamson ether)
Morpholine-4-carboxamide
+
Reactant
(Alkylation of primary amines)
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