| Weight | 247.342 g/mol |
|---|---|
| Formula | C14H21N3O |
| Hydrogen Acceptors | 3 |
| Hydrogen Donors | 2 |
| Aromatic Rings | 1 |
| Rotatable Bonds | 3 |
y-27632 (146986-50-7)
Score:
#48 in Molecular and cellular biology
,
#1627 in Biochemistry
,
#3694 in Biology
,
#4646 in Chemistry
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- Pharmacological Properties of Y-27632, a Specific Inhibitor of Rho-Associated Kinases (Molecular Pharmacology, 2000)
- Modulation of Aqueous Humor Outflow Facility by the Rho KinaseSpecific Inhibitor Y-27632 (Investigative Ophthalmology & Visual Science, 2001)
- Effects of Rho-associated protein kinase inhibitor Y-27632 on intraocular pressure and outflow facility (Investigative Ophthalmology & Visual Science, 2001)
- Use and properties of ROCK-specific inhibitor Y-27632 (Methods in Enzymology, 2000)
- The effects of the Rhokinase inhibitor Y27632 on arachidonic acid, GTPS, and phorbol esterinduced Ca2+sensitization of smooth muscle (FEBS Letters, 1998)
- Y-27632 prevents tubulointerstitial fibrosis in mouse kidneys with unilateral ureteral obstruction (Kidney International, 2002)
-
Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. -
SMILESCC(C1CCC(CC1)C(=O)NC2=CC=NC=C2)N
-
InChIKeyIYOZTVGMEWJPKR-UHFFFAOYSA-N
- Pubchem - y-27632
- Wikipedia - 4-[(1R)-1-aminoethyl]-N-pyridin-4-yl-1-cyclohexanecarboxamide
Y-27632 is a biochemical tool used in the study of the rho-associated protein kinase (ROCK) signaling pathways. Y-27632 selectively inhibits p160ROCK. It has been studied for its effects on corneal endothelial cells(CECs) and cardiac stem cells (CSCs).
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