| Weight | 309.797 g/mol |
|---|---|
| Formula | C15H20ClN3O2 |
| Hydrogen Acceptors | 4 |
| Hydrogen Donors | 2 |
| Aromatic Rings | 1 |
| Rotatable Bonds | 3 |
Zacopride (90182-92-6)
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#1216 in Neuroscience
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#5215 in Biology
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#6836 in Chemistry
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- Quantitative autoradiographic mapping of 5HT3 receptors in the rat CNS using [125I]iodozacopride and [3H]zacopride as radioligands (Synapse, 1992)
- Zacopride: anxiolytic profile in rodent and primate models of anxiety. (Journal of Pharmacy and Pharmacology, 1988)
- Characterisation and autoradiographic localisation of 5-HT3 receptor recognition sites identified with [3H]-(S)-zacopride in the forebrain of the rat (Neuropharmacology, 1990)
- Zacopride, a potent 5-HT3 antagonist (Journal of Pharmacy and Pharmacology, 1988)
- Zacopride, a 5-HT3 receptor antagonist, reduces voluntary ethanol consumption in rats (Pharmacology, Biochemistry and Behavior, 1992)
- [3H]zacopride: ligand for the identification of 5-HT3 recognition sites. (Journal of Pharmacy and Pharmacology, 1988)
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Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. -
SMILESCOC1=CC(=C(C=C1C(=O)NC2CN3CCC2CC3)Cl)N
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InChIKeyFEROPKNOYKURCJ-UHFFFAOYSA-N
- Pubchem - Zacopride
- Wikipedia - zacopride
Zacopride is a potent antagonist at the 5-HT3 receptor and an agonist at the 5-HT4 receptor. It has anxiolytic and nootropic effects in animal models, with the (R)-(+)-enantiomer being the more active form. It also has antiemetic and pro-respiratory effects, both reducing sleep apnea and reversing opioid-induced respiratory depression in animal studies.
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