| Weight | 273.244 g/mol |
|---|---|
| Formula | C14H11NO5 |
| Hydrogen Acceptors | 5 |
| Hydrogen Donors | 2 |
| Aromatic Rings | 2 |
| Rotatable Bonds | 3 |
Tolcapone (134308-13-7)
Score:
#107 in Neurology
,
#516 in Neuroscience
,
#2385 in Biology
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- Tolcapone : COMT Inhibition for the Treatment of Parkinson's disease (Neurology, 1998)
- Tolcapone Improves Motor Function and Reduces Levodopa Requirement in Patients with Parkinson's Disease Experiencing Motor Fluctuations A Multicenter, Double-Blind, Randomized, Placebo-Controlled Trial (Neurology, 1997)
- Tolcapone improves motor function in parkinsonian patients with the"wearing-off" phenomenon: A double-blind, placebo-controlled, multicenter trial (Neurology, 1997)
- Tolcapone improves cognition and cortical information processing in normal human subjects (Neuropsychopharmacology, 2007)
- Tolcapone and fulminant hepatitis (The Lancet, 1998)
- Catechol-O-methyltransferase inhibition with tolcapone reduces the wearing off phenomenon and levodopa requirements in fluctuating parkinsonian patients (Journal of Neurology, Neurosurgery, and Psychiatry, 1997)
-
SMILESCC1=CC=C(C=C1)C(=O)C2=CC(=C(C(=C2)O)O)[N+](=O)[O-]
-
InChIKeyMIQPIUSUKVNLNT-UHFFFAOYSA-N
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