| Weight | 164.212 g/mol |
|---|---|
| Formula | C8H12N4 |
| Hydrogen Acceptors | 4 |
| Hydrogen Donors | 1 |
| Aromatic Rings | 1 |
| Rotatable Bonds | 1 |
2-(1-Piperazinyl)pyrimidine (125523-53-7, 20980-22-7)
MJ-13653 · 1-(2-pyrimidinyl)piperazine · MJ 13653
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- Piperazine-based CCR5 antagonists as HIV-1 inhibitors. IV. Discovery of 1-[(4,6-dimethyl-5-pyrimidinyl)carbonyl]- 4-[4-[2-methoxy-1(R)-4-(trifluoromethyl)phenyl]ethyl-3(S)-methyl-1-piperazinyl]- 4-methylpiperidine (Sch-417690/Sch-D), a potent, highly selective, and orally bioavailable CCR5 antagonist. (Journal of Medicinal Chemistry, 2004)
- 1-(2-Pyrimidinyl)-Piperazine as Active Metabolite of Buspirone in Man and Rat (Pharmacology, 1986)
- Pyrido[2,3-d]pyrimidine antibacterial agents. 3. 8-Alkyl- and 8-vinyl-5,8-dihydro-5-oxo-2-(1-piperazinyl)pyrido[2,3-d]pyrimidine-6-carboxylic acids and their derivatives (Journal of Medicinal Chemistry, 1975)
- Effects of buspirone and its metabolite, 1-(2-pyrimidinyl)piperazine, on brain monoamines and their metabolites in rats. (Journal of Pharmacology and Experimental Therapeutics, 1989)
- Tandospirone and its metabolite, 1-(2-pyrimidinyl)-piperazineI. Effects of acute and long-term administration of tandospirone on serotonin neurotransmission (Neuropharmacology, 1991)
- The 2-adrenoceptor antagonist activity of ipsapirone and gepirone is mediated by their common metabolite 1-(2-pyrimidinyl)-piperazine (PmP) (European Journal of Pharmacology, 1988)
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Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. - MJ-13653
- 1-(2-pyrimidinyl)piperazine
- MJ 13653
-
SMILESC1CN(CCN1)C2=NC=CC=N2
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InChIKeyMRBFGEHILMYPTF-UHFFFAOYSA-N
- Pubchem - 2-(1-Piperazinyl)pyrimidine
- Wikipedia - 1-(2-pyrimidinyl)piperazine
1-(2-Pyrimidinyl)piperazine (1-PP, 1-PmP) is a chemical compound and piperazine derivative. It is known to act as an antagonist of the 2-adrenergic receptor (Ki = 7.340nM) and, to a much lesser extent, as a partial agonist of the 5-HT1A receptor (Ki = 414nM; Emax = 54%). It has negligible affinity for the dopamine D2, D3, and D4 receptors (Ki > 10,000nM) and does not appear to have significant affinity for the 1-adrenergic receptors.
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