| Weight | 111.1 g/mol |
|---|---|
| Formula | C5H5NO2 |
| Hydrogen Acceptors | 2 |
| Hydrogen Donors | 2 |
| Aromatic Rings | 1 |
| Rotatable Bonds | 0 |
2,5-Dihydroxypyridine (5154-01-8)
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- Antitumor Activity of 1 m Tegafur-0.4 m 5-Chloro-2,4-dihydroxypyridine-1 m Potassium Oxonate (S-1) against Human Colon Carcinoma Orthotopically Implanted into Nude Rats (Cancer Research, 1996)
- Determination of S-1 (combined drug of tegafur, 5-chloro-2,4-dihydroxypyridine and potassium oxonate) and 5-fluorouracil in human plasma and urine using high-performance liquid chromatography and gas chromatography-negative ion chemical ionization mass spectrometry. (Journal of Chromatography B: Biomedical Sciences and Applications, 1997)
- Enhancement of the antitumour activity of 5-fluorouracil (5-FU) by inhibiting dihydropyrimidine dehydrogenase activity (DPD) using 5-chloro-2,4-dihydroxypyridine (CDHP) in human tumour cells (European Journal of Cancer, 2002)
- CYP2A6 and the plasma level of 5-chloro-2, 4-dihydroxypyridine are determinants of the pharmacokinetic variability of tegafur and 5-fluorouracil, respectively, in Japanese patients with cancer given S-1 (Cancer Science, 2008)
- Pharmacokinetics of S-1, an oral formulation of ftorafur, oxonic acid and 5-chloro-2,4-dihydroxypyridine (molar ratio 1:0.4:1) in patients with solid tumors (Cancer Chemotherapy and Pharmacology, 2003)
- The metabolism of nicotinic acid. I. Purification and properties of 2,5-dihydroxypyridine oxygenase from Pseudomonas putida N-9. (Journal of Biological Chemistry, 1971)
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Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. -
SMILESC1=CC(=O)NC=C1O
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InChIKeyCHGPEDOMXOLANF-UHFFFAOYSA-N
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